INT286591

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Context Info
Confidence 0.07
First Reported 2007
Last Reported 2007
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.17
Pain Relevance 0.06

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (PKD1, Id2) cytoplasm (PKD1, Id2) cytosol (Id2)
plasma membrane (PKD1) cilium (PKD1) protein complex (Id2)
Anatomy Link Frequency
nucleus 1
PKD1 (Homo sapiens)
Id2 (Mus musculus)
Pain Link Frequency Relevance Heat
Mechanosensation 4 62.80 Quite High
Mechanotransduction 1 30.24 Quite Low
Somatostatin 4 5.00 Very Low Very Low Very Low
imagery 3 5.00 Very Low Very Low Very Low
fibrosis 2 5.00 Very Low Very Low Very Low
abdominal pain 1 5.00 Very Low Very Low Very Low
Kinase C 1 5.00 Very Low Very Low Very Low
antagonist 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Stress 2 59.08 Quite High
Polycystic Kidney Disease 62 56.24 Quite High
Apoptosis 17 52.44 Quite High
Cyst 32 5.00 Very Low Very Low Very Low
Disease 30 5.00 Very Low Very Low Very Low
Adhesions 19 5.00 Very Low Very Low Very Low
Cystic Kidney Diseases 8 5.00 Very Low Very Low Very Low
Congenital Anomalies 6 5.00 Very Low Very Low Very Low
Targeted Disruption 5 5.00 Very Low Very Low Very Low
Syndrome 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In PKD, when PC-1 or PC-2 are inactivated, Id2 translocates to the nucleus and interacts with E-protein, blocking its ability to induce growth-suppressive genes and resulting in increased activity of cdk2 and activation of cell proliferation; (2) PC-1 can activate the JAK/STAT signaling pathway, resulting in the induction of p21waf1 and cell cycle arrest in G0 and G1; (3) The intraflagellar transport component IFT88/polaris is capable of controlling G1/S transition of the cell cycle.
PC-1 Binding (interacts) of Id2 in nucleus
1) Confidence 0.07 Published 2007 Journal Cell Mol Life Sci Section Body Doc Link PMC2775119 Disease Relevance 0.17 Pain Relevance 0.06

General Comments

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