INT286615

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Context Info
Confidence 0.31
First Reported 2009
Last Reported 2011
Negated 0
Speculated 0
Reported most in Body
Documents 7
Total Number 8
Disease Relevance 5.22
Pain Relevance 0.70

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Ide) mitochondrion (Ide) extracellular space (Ide)
ATPase activity (Ide) nucleus (Ide)
Anatomy Link Frequency
liver 1
muscle tissues 1
Ide (Mus musculus)
Pain Link Frequency Relevance Heat
Eae 23 100.00 Very High Very High Very High
antagonist 2 94.40 High High
Inflammation 50 88.20 High High
Central nervous system 3 77.16 Quite High
adenocard 2 76.60 Quite High
amygdala 28 75.88 Quite High
Hippocampus 14 74.96 Quite High
anesthesia 5 74.12 Quite High
imagery 9 68.84 Quite High
alcohol 12 50.00 Quite Low
Disease Link Frequency Relevance Heat
Targeted Disruption 208 99.66 Very High Very High Very High
Disease 231 99.00 Very High Very High Very High
Diabetes Mellitus 112 90.56 High High
Toxicity 11 90.56 High High
INFLAMMATION 53 88.20 High High
Alzheimer's Dementia 63 86.96 High High
Hypothermia 9 86.84 High High
Obesity 14 83.28 Quite High
Coronary Heart Disease 4 74.72 Quite High
Hyperglycemia 12 70.28 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Indeed, the level of insulin-induced phosphorylation of PKB and GSK-3 was similar in liver and muscle tissues of both Alb Cre + and Alb Cre – mice (figure 5A and 5B respectively).
Phosphorylation (phosphorylation) of insulin in muscle tissues
1) Confidence 0.31 Published 2011 Journal PLoS ONE Section Body Doc Link PMC3017066 Disease Relevance 0.38 Pain Relevance 0
Furthermore, insulin can modulate tau phosphorylation in vitro [17] and in non-transgenic mice, depletion of insulin results in increased tau phosphorylation, with no concomitant formation of pathological tau deposits [18], [19].
Phosphorylation (phosphorylation) of insulin associated with targeted disruption and eae
2) Confidence 0.26 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2775636 Disease Relevance 1.99 Pain Relevance 0.14
In contrast to STZ-injected non-transgenic mice, increased hyperphosphorylation of tau in insulin-depleted pR5 mice was associated with abundant amounts of insoluble tau and 8-fold increased formation of NFTs.
Phosphorylation (hyperphosphorylation) of insulin associated with targeted disruption
3) Confidence 0.25 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2775636 Disease Relevance 0.59 Pain Relevance 0.13
Interestingly, this was not associated with the formation of insoluble tau aggregates or NFTs, suggesting that hyperphosphorylation of tau upon insulin depletion in itself is not sufficient to induce its deposition.
Phosphorylation (hyperphosphorylation) of insulin
4) Confidence 0.20 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2775636 Disease Relevance 0.63 Pain Relevance 0.22
In summary, the present study has provided convincing evidence that cardiac overexpression of ADH exacerbated acute ethanol exposure-induced myocardial contractile and intracellular Ca2+ dysregulation associated with altered insulin sensitivity and hyperphosphorylated AMPK signaling.
Phosphorylation (hyperphosphorylated) of insulin
5) Confidence 0.12 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2890411 Disease Relevance 0.31 Pain Relevance 0
Indeed, the level of insulin-induced phosphorylation of PKB and GSK-3 was similar in liver and muscle tissues of both Alb Cre + and Alb Cre – mice (figure 5A and 5B respectively).
Phosphorylation (phosphorylation) of insulin in liver
6) Confidence 0.11 Published 2011 Journal PLoS ONE Section Body Doc Link PMC3017066 Disease Relevance 0.38 Pain Relevance 0
binds to insulin receptors and affects its autophosphorylation in the presence of insulin.
Phosphorylation (autophosphorylation) of insulin
7) Confidence 0.05 Published 2010 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2938309 Disease Relevance 0.36 Pain Relevance 0.12
-induced phosphorylation of insulin receptor substrate (IRS) by tau kinases.
Phosphorylation (phosphorylation) of insulin
8) Confidence 0.05 Published 2010 Journal Mol Neurobiol Section Body Doc Link PMC2876259 Disease Relevance 0.59 Pain Relevance 0.08

General Comments

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