INT28667

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Context Info
Confidence 0.16
First Reported 1989
Last Reported 2001
Negated 0
Speculated 0
Reported most in Abstract
Documents 4
Total Number 5
Disease Relevance 5.84
Pain Relevance 4.11

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
nerve 1
peripheral nerve 1
Ean5 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Neuritis 41 100.00 Very High Very High Very High
tolerance 26 99.86 Very High Very High Very High
Inflammation 6 97.56 Very High Very High Very High
Sciatic nerve 1 78.16 Quite High
Peripheral nervous system 2 75.84 Quite High
Demyelination 1 75.00 Quite High
Disease Link Frequency Relevance Heat
Experimental Autoimmune Neuritis 41 100.00 Very High Very High Very High
Immunization 12 100.00 Very High Very High Very High
Demyelinating Disease 5 98.12 Very High Very High Very High
INFLAMMATION 6 97.56 Very High Very High Very High
Disease 8 95.96 Very High Very High Very High
Syndrome 3 94.72 High High
Neuropathic Pain 1 92.64 High High
Vibrio Infection 4 92.24 High High
Nervous System Injury 1 67.04 Quite High
Autoimmune Disease 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Early injection of ART 18 suppressed AT-EAN while treatment after appearance of clinical signs did not.
Negative_regulation (suppressed) of AT-EAN
1) Confidence 0.16 Published 1989 Journal Brain Res. Section Abstract Doc Link 2787191 Disease Relevance 0.17 Pain Relevance 0.21
The findings suggest that immunogenicity of the antigens fed determine strength of tolerance, that downregulation of EAN occurs at the site of immunization and not in the nerve, and that active suppression rather than specific anergization is operative in mediating resistance to EAN.
Negative_regulation (downregulation) of EAN in nerve associated with immunization, tolerance and neuritis
2) Confidence 0.11 Published 1997 Journal J. Neuroimmunol. Section Abstract Doc Link 9394785 Disease Relevance 1.55 Pain Relevance 1.05
Clinical signs of EAN actively induced by immunization with bovine peripheral nerve myelin in complete Freund's adjuvant (CFA) were totally prevented or markedly suppressed by preventative injections of OX34 starting 8 days post-immunization (p.i.).
Negative_regulation (suppressed) of EAN in peripheral nerve associated with immunization and neuritis
3) Confidence 0.11 Published 1996 Journal Brain Section Abstract Doc Link 8813272 Disease Relevance 1.65 Pain Relevance 0.77
We previously demonstrated that EAN actively induced by immunization with bovine PNS-myelin can be suppressed by feeding of myelin.
Negative_regulation (suppressed) of EAN associated with immunization and neuritis
4) Confidence 0.10 Published 2001 Journal J. Neuroimmunol. Section Abstract Doc Link 11311326 Disease Relevance 1.20 Pain Relevance 0.98
Adjuvant effects and bystander suppression in P2 peptide-induced EAN.
Negative_regulation (suppression) of EAN associated with neuritis
5) Confidence 0.09 Published 2001 Journal J. Neuroimmunol. Section Title Doc Link 11311326 Disease Relevance 1.27 Pain Relevance 1.10

General Comments

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