INT286679

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Context Info
Confidence 0.42
First Reported 2009
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 2.43
Pain Relevance 0.26

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Maob) oxidoreductase activity (Maob)
Maob (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 2 97.88 Very High Very High Very High
addiction 12 82.08 Quite High
alcohol 2 81.64 Quite High
Nicotine 4 81.12 Quite High
monoamine 12 50.00 Quite Low
Serotonin 6 5.00 Very Low Very Low Very Low
sSRI 4 5.00 Very Low Very Low Very Low
Restless leg syndrome 2 5.00 Very Low Very Low Very Low
depression 2 5.00 Very Low Very Low Very Low
ischemia 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Nicotine Addiction 342 99.78 Very High Very High Very High
INFLAMMATION 2 97.88 Very High Very High Very High
Cancer 6 90.44 High High
Lung Cancer 6 86.92 High High
Colon Cancer 2 65.60 Quite High
Suicidal Behaviour 2 52.16 Quite High
Atherosclerosis 6 5.00 Very Low Very Low Very Low
Hypertension 4 5.00 Very Low Very Low Very Low
Obesity 4 5.00 Very Low Very Low Very Low
Cardiovascular Disorder Under Development 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The persistence of increased protein concentrations of MAO-B was unexpected, even though some haematological and inflammation characteristics remain modified for several years after quitting smoking [19], [35], [36].
Negative_regulation (persistence) of Positive_regulation (increased) of MAO-B associated with nicotine addiction and inflammation
1) Confidence 0.42 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2775922 Disease Relevance 1.28 Pain Relevance 0.08
Both S and FS exhibited reduced methylation of the MAOB promoter, leading to a more active transcription of the gene and hence a greater protein concentration of MAO-B.
Negative_regulation (reduced) of Positive_regulation (methylation) of MAOB associated with nicotine addiction
2) Confidence 0.42 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2775922 Disease Relevance 1.15 Pain Relevance 0.19

General Comments

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