INT2867

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Context Info
Confidence 0.78
First Reported 1977
Last Reported 2011
Negated 11
Speculated 11
Reported most in Abstract
Documents 247
Total Number 263
Disease Relevance 78.78
Pain Relevance 138.47

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (CALCA) aging (CALCA) extracellular region (CALCA)
nucleus (CALCA) intracellular (CALCA) cell-cell signaling (CALCA)
Anatomy Link Frequency
endothelial cells 12
nerves 9
plasma 7
teeth 7
tear 5
CALCA (Homo sapiens)
Pain Link Frequency Relevance Heat
Calcitonin gene-related peptide 5973 100.00 Very High Very High Very High
Neuropeptide 1002 100.00 Very High Very High Very High
qutenza 811 100.00 Very High Very High Very High
substance P 784 100.00 Very High Very High Very High
antagonist 738 100.00 Very High Very High Very High
Inflammation 467 100.00 Very High Very High Very High
Pain 219 100.00 Very High Very High Very High
calcitonin gene related peptide 144 100.00 Very High Very High Very High
Enkephalin 49 100.00 Very High Very High Very High
Somatostatin 30 100.00 Very High Very High Very High
Disease Link Frequency Relevance Heat
Disease 284 100.00 Very High Very High Very High
Esophageal Disease 199 100.00 Very High Very High Very High
Pain 192 100.00 Very High Very High Very High
Cancer 138 100.00 Very High Very High Very High
Osteoporosis 85 100.00 Very High Very High Very High
Neurogenic Inflammation 48 100.00 Very High Very High Very High
Inflammatory Bowel Disease 9 100.00 Very High Very High Very High
Natriuresis 7 100.00 Very High Very High Very High
Shock 4 100.00 Very High Very High Very High
Increased Venous Pressure Under Development 173 99.96 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
OBJECTIVE: To elucidate the expression of calcitonin gene-related peptide (CGRP) in synovial tissue taken from the human temporomandibular joint (TMJ) with internal derangement, and discuss the relationship between CGRP and joint pain.
Gene_expression (expression) of calcitonin gene-related peptide in joint associated with pain, arthralgia, snapping jaw and calcitonin gene-related peptide
1) Confidence 0.78 Published 2004 Journal Oral Surg Oral Med Oral Pathol Oral Radiol Endod Section Abstract Doc Link 15529124 Disease Relevance 0.34 Pain Relevance 0.53
OBJECTIVE: To elucidate the expression of calcitonin gene-related peptide (CGRP) in synovial tissue taken from the human temporomandibular joint (TMJ) with internal derangement, and discuss the relationship between CGRP and joint pain.
Gene_expression (expression) of CGRP in joint associated with pain, arthralgia, snapping jaw and calcitonin gene-related peptide
2) Confidence 0.78 Published 2004 Journal Oral Surg Oral Med Oral Pathol Oral Radiol Endod Section Abstract Doc Link 15529124 Disease Relevance 0.34 Pain Relevance 0.53
CONCLUSIONS: These results suggest that the expression of CGRP is increased in the synovial tissues from patients with internal derangement, and that CGRP seems to play an important role in the mechanism of pain production in patients with symptomatic internal derangement.


Gene_expression (expression) of CGRP in internal
3) Confidence 0.78 Published 2004 Journal Oral Surg Oral Med Oral Pathol Oral Radiol Endod Section Body Doc Link 15529124 Disease Relevance 0.14 Pain Relevance 0
However, immunohistochemical studies, tissue assays, and in vitro cultures documented production of several peptides, including calcitonin gene-related peptide and vasoactive intestinal polypeptide in tumor cells.
Gene_expression (production) of calcitonin associated with cancer and calcitonin gene-related peptide
4) Confidence 0.78 Published 1992 Journal Arch Surg Section Abstract Doc Link 1734841 Disease Relevance 0.96 Pain Relevance 0.17
CGRP-IR was also present in epithelial endocrine cells and neuroepithelial bodies.
Gene_expression (present) of CGRP-IR in endocrine cells associated with calcitonin gene-related peptide
5) Confidence 0.78 Published 1988 Journal Regul. Pept. Section Abstract Doc Link 2452458 Disease Relevance 0 Pain Relevance 0.97
AIM: The purpose of this study was to investigate the levels of substance P (SP), neurokinin A (NKA) and calcitonin gene-related peptide (CGRP) in painful and healthy human dental pulps.
Spec (investigate) Gene_expression (levels) of CGRP in dental pulps associated with pain, calcitonin gene-related peptide and substance p
6) Confidence 0.78 Published 2002 Journal Int Endod J Section Abstract Doc Link 11853236 Disease Relevance 0 Pain Relevance 0.35
AIM: The purpose of this study was to investigate the levels of substance P (SP), neurokinin A (NKA) and calcitonin gene-related peptide (CGRP) in painful and healthy human dental pulps.
Spec (investigate) Gene_expression (levels) of calcitonin gene-related peptide in dental pulps associated with pain, calcitonin gene-related peptide and substance p
7) Confidence 0.78 Published 2002 Journal Int Endod J Section Abstract Doc Link 11853236 Disease Relevance 0 Pain Relevance 0.35
CGRP is found in most all tissues and is considered to be a neuromediator of particular importance in the cardiovascular system.
Gene_expression (found) of CGRP in cardiovascular system associated with calcitonin gene-related peptide
8) Confidence 0.78 Published 1994 Journal Presse Med Section Abstract Doc Link 8177860 Disease Relevance 0.53 Pain Relevance 0.49
Calcitonin (CT) is a polypeptide hormone produced in the thyroid gland that regulates, blood calcium levels and bone calcium metabolism.
Gene_expression (produced) of Calcitonin in blood
9) Confidence 0.78 Published 1994 Journal Agents Actions Section Abstract Doc Link 7942319 Disease Relevance 0.05 Pain Relevance 0.17
Expression of calcitonin gene-related peptide (CGRP) in irreversible acute pulpitis.
Gene_expression (Expression) of CGRP associated with pulpitis and calcitonin gene-related peptide
10) Confidence 0.77 Published 2004 Journal J Endod Section Title Doc Link 15085045 Disease Relevance 0.58 Pain Relevance 0.84
Calcitonin gene-related peptide (CGRP), the principal transmitter in sensory nerves, could also be expressed in vascular endothelium.
Gene_expression (expressed) of Calcitonin gene-related peptide in vascular endothelium associated with calcitonin gene-related peptide
11) Confidence 0.77 Published 2008 Journal Regul. Pept. Section Abstract Doc Link 18584893 Disease Relevance 0.12 Pain Relevance 0.36
HUVECs expressed CGRP, both alpha- and beta-subtype.
Gene_expression (expressed) of CGRP associated with calcitonin gene-related peptide
12) Confidence 0.77 Published 2008 Journal Regul. Pept. Section Abstract Doc Link 18584893 Disease Relevance 0.27 Pain Relevance 0.89
Transient receptor potential vanilloid 1-mediated expression and secretion of endothelial cell-derived calcitonin gene-related peptide.
Gene_expression (expression) of calcitonin gene-related peptide in endothelial cell associated with qutenza and calcitonin gene-related peptide
13) Confidence 0.77 Published 2008 Journal Regul. Pept. Section Title Doc Link 18584893 Disease Relevance 0.21 Pain Relevance 0.92
Capsaicin increased the level of CGRP in the culture medium, and up-regulated the expression of CGRP in endothelial cells.
Gene_expression (expression) of CGRP in endothelial cells associated with qutenza and calcitonin gene-related peptide
14) Confidence 0.77 Published 2008 Journal Regul. Pept. Section Abstract Doc Link 18584893 Disease Relevance 0.27 Pain Relevance 0.92
Calcitonin gene-related peptide (CGRP), the principal transmitter in sensory nerves, could also be expressed in vascular endothelium.
Gene_expression (expressed) of CGRP in vascular endothelium associated with calcitonin gene-related peptide
15) Confidence 0.77 Published 2008 Journal Regul. Pept. Section Abstract Doc Link 18584893 Disease Relevance 0.12 Pain Relevance 0.36
These results indicate that TRPV1 also regulates the expression and secretion of endothelial cell-derived CGRP, which affords protective effects on endothelial cells.
Gene_expression (expression) of CGRP in endothelial cells associated with calcitonin gene-related peptide
16) Confidence 0.77 Published 2008 Journal Regul. Pept. Section Abstract Doc Link 18584893 Disease Relevance 0.23 Pain Relevance 0.81
The effect of clonidine on endothelial cell-derived CGRP synthesis and secretion was attenuated in the presence of yohimbine.
Gene_expression (synthesis) of CGRP in endothelial cell associated with calcitonin gene-related peptide and clonidine
17) Confidence 0.76 Published 2009 Journal Peptides Section Abstract Doc Link 19520131 Disease Relevance 0 Pain Relevance 1.19
The study showed that clonidine was able to induce CGRP mRNA (alpha- and beta-isoforms) expression in a dose-dependent manner in endothelial cells.
Gene_expression (expression) of CGRP in endothelial cells associated with calcitonin gene-related peptide and clonidine
18) Confidence 0.76 Published 2009 Journal Peptides Section Abstract Doc Link 19520131 Disease Relevance 0 Pain Relevance 1.20
These results suggest that clonidine could stimulate CGRP synthesis and secretion in endothelial cells through the activation of alpha(2)-adrenoceptor, which is related to the NO pathway.
Gene_expression (synthesis) of CGRP in endothelial cells associated with calcitonin gene-related peptide and clonidine
19) Confidence 0.76 Published 2009 Journal Peptides Section Abstract Doc Link 19520131 Disease Relevance 0 Pain Relevance 1.11
The present study was to determine whether clonidine could induce calcitonin gene-related peptide (CGRP) production and the underlying mechanisms.
Gene_expression (production) of CGRP associated with calcitonin gene-related peptide and clonidine
20) Confidence 0.76 Published 2009 Journal Peptides Section Abstract Doc Link 19520131 Disease Relevance 0 Pain Relevance 0.76

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