INT286707

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Context Info
Confidence 0.37
First Reported 2009
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.18
Pain Relevance 0.28

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoplasm (Mapk1, Rps6ka5) nucleus (Mapk1, Rps6ka5) kinase activity (Mapk1, Rps6ka5)
nucleoplasm (Mapk1) mitochondrion (Mapk1) protein complex (Mapk1)
Anatomy Link Frequency
neurons 2
Mapk1 (Mus musculus)
Rps6ka5 (Mus musculus)
Pain Link Frequency Relevance Heat
cocaine 1 99.32 Very High Very High Very High
Nucleus accumbens 32 91.72 High High
antagonist 11 72.64 Quite High
Dopamine 49 71.76 Quite High
Eae 9 66.68 Quite High
Substantia nigra 1 52.72 Quite High
Serotonin 12 50.00 Quite Low
GABAergic 2 44.84 Quite Low
sSRI 5 5.00 Very Low Very Low Very Low
Ventral tegmentum 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Stress 1 100.00 Very High Very High Very High
Targeted Disruption 4 83.04 Quite High
Drug Dependence 4 5.00 Very Low Very Low Very Low
Recurrence 2 5.00 Very Low Very Low Very Low
Body Weight 1 5.00 Very Low Very Low Very Low
Fever 1 5.00 Very Low Very Low Very Low
Serotonin Syndrome 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Activated ERK, in turn, induces CREB phosphorylation, c-Fos expression, mitogen- and stress-activated kinase-1 (MSK1) activation and histone H3 phosphorylation, all of which further regulate gene expression in D1 receptor-expressing neurons [42], [43].
ERK Positive_regulation (induces) of Positive_regulation (activation) of MSK1 in neurons associated with stress
1) Confidence 0.37 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2775951 Disease Relevance 0.18 Pain Relevance 0.28

General Comments

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