INT28671

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Context Info
Confidence 0.67
First Reported 1989
Last Reported 2011
Negated 0
Speculated 1
Reported most in Body
Documents 43
Total Number 44
Disease Relevance 22.85
Pain Relevance 8.39

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (HLA-E)
Anatomy Link Frequency
microglia 9
T cells 9
brain 4
CD86 4
limb 4
HLA-E (Homo sapiens)
Pain Link Frequency Relevance Heat
aspirin 168 99.78 Very High Very High Very High
midbrain 6 99.36 Very High Very High Very High
Peripheral nervous system 5 99.36 Very High Very High Very High
Inflammation 512 99.10 Very High Very High Very High
tetrodotoxin 4 98.76 Very High Very High Very High
cytokine 322 98.32 Very High Very High Very High
Action potential 3 97.68 Very High Very High Very High
Substantia nigra 51 96.68 Very High Very High Very High
Chronic pancreatitis 6 96.32 Very High Very High Very High
dorsal root ganglion 2 95.68 Very High Very High Very High
Disease Link Frequency Relevance Heat
Adhesions 38 100.00 Very High Very High Very High
Hypertrophy 32 99.88 Very High Very High Very High
Stress 28 99.82 Very High Very High Very High
Hepatitis C Virus Infection 72 99.72 Very High Very High Very High
Disease 456 99.66 Very High Very High Very High
Diabetes Mellitus 23 99.66 Very High Very High Very High
Cancer 401 99.44 Very High Very High Very High
INFLAMMATION 607 99.10 Very High Very High Very High
Aging 11 98.68 Very High Very High Very High
Cytomegalovirus Infection 9 98.68 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Immunocytochemistry revealed only occasional lymphocyte infiltration but there was increased Class I and Class II MHC antigen expression throughout the peripheral nervous system.
Positive_regulation (increased) of Gene_expression (expression) of MHC in lymphocyte associated with peripheral nervous system
1) Confidence 0.67 Published 1989 Journal Neuropathol. Appl. Neurobiol. Section Abstract Doc Link 2787483 Disease Relevance 0.74 Pain Relevance 0.30
Activated microglial cells show an increased expression of MHC class I and II antigens.
Positive_regulation (increased) of Gene_expression (expression) of MHC in microglial cells
2) Confidence 0.67 Published 1993 Journal Glia Section Abstract Doc Link 8380791 Disease Relevance 1.01 Pain Relevance 0.54
Infiltration of the pancreas by particular subsets of immune effector cells, aberrant and enhanced expression of MHC molecules, and overexpression of growth factors and their receptors have all recently been found to play a role in CP.
Positive_regulation (enhanced) of Gene_expression (expression) of MHC in pancreas associated with chronic pancreatitis
3) Confidence 0.67 Published 2001 Journal Zentralbl Chir Section Abstract Doc Link 11753795 Disease Relevance 0.76 Pain Relevance 0.58
The immunohistological analysis of the endomyocardial biopsy specimens revealed pathologically increased lymphocytic infiltrates and increased expression of interstitial and endothelial MHC I and II antigens.
Positive_regulation (increased) of Gene_expression (expression) of MHC
4) Confidence 0.67 Published 2002 Journal Z Kardiol Section Body Doc Link 12132290 Disease Relevance 0.16 Pain Relevance 0
All of the models discussed resulted in increased expression of fast MHC isoforms at the protein and/or mRNA levels in slow and fast muscles (with the possible exception of unilateral limb unloading in humans).
Positive_regulation (resulted) of Gene_expression (expression) of MHC in limb
5) Confidence 0.53 Published 2000 Journal Muscle Nerve Section Abstract Doc Link 10797389 Disease Relevance 0.17 Pain Relevance 0.28
In this review, the adaptations in myosin heavy chain (MHC) isoform expression induced by chronic reductions in neuromuscular activity (including electrical activation and load bearing) of the intact neuromuscular unit are summarized and evaluated.
Positive_regulation (induced) of Gene_expression (expression) of MHC
6) Confidence 0.53 Published 2000 Journal Muscle Nerve Section Abstract Doc Link 10797389 Disease Relevance 0.12 Pain Relevance 0.06
MHCI expression in the visual cortex is activity dependent
Positive_regulation (dependent) of Gene_expression (expression) of MHC in cortex
7) Confidence 0.49 Published 2011 Journal Behav Brain Funct Section Body Doc Link PMC3023691 Disease Relevance 0 Pain Relevance 0
Activated microglia express high levels of MHC glycoproteins and receptors for complement.
Positive_regulation (levels) of Gene_expression (express) of MHC in microglia
8) Confidence 0.49 Published 1996 Journal Ann. N. Y. Acad. Sci. Section Abstract Doc Link 8624086 Disease Relevance 0.61 Pain Relevance 0.13
Both B- and T-cell responses towards peripheral myelin were suppressed by the IFN-beta, and immunohistochemical analyses revealed a strong decrease in the numbers of infiltrating CD4(+) T cells, macrophages, and other inflammatory cells as well as a significant reduction in MHC class II antigen expression and monocyte chemotactic protein-1 (MCP-1) production, which induces chemotaxis and chemokinesis of leukocytes from blood.
Positive_regulation (induces) of Gene_expression (expression) of MHC in T cells associated with inflammation
9) Confidence 0.49 Published 1999 Journal J. Neurosci. Res. Section Abstract Doc Link 10494101 Disease Relevance 0.89 Pain Relevance 0.74
Prolonged resistance training has been reported to increase the mRNA and protein expression of the MHC type IIa isoform while decreasing type IIx and minimally altering type I isoform expression patterns [43].
Positive_regulation (increase) of Gene_expression (expression) of MHC
10) Confidence 0.45 Published 2007 Journal J Int Soc Sports Nutr Section Body Doc Link PMC2217562 Disease Relevance 0.42 Pain Relevance 0.16
All of the models discussed resulted in increased expression of fast MHC isoforms at the protein and/or mRNA levels in slow and fast muscles (with the possible exception of unilateral limb unloading in humans).
Spec (possible) Positive_regulation (increased) of Gene_expression (expression) of MHC in limb
11) Confidence 0.36 Published 2000 Journal Muscle Nerve Section Abstract Doc Link 10797389 Disease Relevance 0.17 Pain Relevance 0.28
Nonetheless, it was assumed that the ostensible inflammation in AD is of a chronic and therefore detrimental nature because AD is after all an aging-related condition and a number of studies had shown a progressive increase in the expression of MHC class II antigens in the normal aging brain (Rogers et al., 1988; Perry et al., 1993; Ogura et al., 1994; Sheffield and Berman, 1998), suggesting that normal aging is accompanied by inflammation.
Positive_regulation (increase) of Gene_expression (expression) of MHC in brain associated with aging, inflammation and disease
12) Confidence 0.29 Published 2010 Journal Frontiers in Aging Neuroscience Section Body Doc Link PMC2890154 Disease Relevance 1.88 Pain Relevance 0.35
Further studies that correlate ERAP2 genotype with levels of MHC class I expression in other tissues, and with the presentation and recognition of specific antigens, are needed to more clearly define the influence of ERAP2 deficiency on immune response.
Positive_regulation (levels) of Gene_expression (expression) of MHC
13) Confidence 0.24 Published 2010 Journal PLoS Genetics Section Body Doc Link PMC2954825 Disease Relevance 0.29 Pain Relevance 0.07
Haplotype B homozygotes had lower levels of MHC class I expressed on the surface of B cells, suggesting that naturally occurring ERAP2 deficiency affects MHC presentation and immune response.
Positive_regulation (levels) of Gene_expression (expressed) of MHC in B cells
14) Confidence 0.24 Published 2010 Journal PLoS Genetics Section Abstract Doc Link PMC2954825 Disease Relevance 0 Pain Relevance 0
Nonetheless, the notion that MHC II expression can serve as an objective biomolecular marker for activated microglia was seemingly corroborated by subsequent animal studies that showed increases in MHC II expression on a subset of microglial cells following experimental lesions (Akiyama et al., 1988; Streit et al., 1989; Smetanka et al., 1990), encouraging its widespread acceptance.
Positive_regulation (increases) of Gene_expression (expression) of MHC in microglia
15) Confidence 0.21 Published 2010 Journal Frontiers in Aging Neuroscience Section Body Doc Link PMC2890154 Disease Relevance 0.32 Pain Relevance 0.05
Both B- and T-cell responses towards peripheral myelin were suppressed by the IFN-beta, and immunohistochemical analyses revealed a strong decrease in the numbers of infiltrating CD4(+) T cells, macrophages, and other inflammatory cells as well as a significant reduction in MHC class II antigen expression and monocyte chemotactic protein-1 (MCP-1) production, which induces chemotaxis and chemokinesis of leukocytes from blood.
Positive_regulation (induces) of in macrophages Gene_expression (expression) of MHC in T cells associated with inflammation
16) Confidence 0.17 Published 1999 Journal J. Neurosci. Res. Section Abstract Doc Link 10494101 Disease Relevance 0.89 Pain Relevance 0.74
The increased expression of HLA-E indicates that epithelial cells were actively protected from potentially damaging immune system responses.
Positive_regulation (increased) of Gene_expression (expression) of HLA-E in immune system
17) Confidence 0.12 Published 2008 Journal BMC Genomics Section Body Doc Link PMC2519092 Disease Relevance 0.21 Pain Relevance 0
Stabilization of HLA-E expression is among others mediated by HLA-A2 [33] and the expression of this protein is also upregulated after 6 h.
Positive_regulation (Stabilization) of Gene_expression (expression) of HLA-E
18) Confidence 0.12 Published 2008 Journal BMC Genomics Section Body Doc Link PMC2519092 Disease Relevance 0.26 Pain Relevance 0.03
The fact that increased expression of MHC class I molecules may predispose to heavy-chain dimer formation may be relevant in other alleles as well as HLA-B27.
Positive_regulation (increased) of Gene_expression (expression) of MHC class I
19) Confidence 0.11 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2575614 Disease Relevance 0.59 Pain Relevance 0.14
Although induction of MHC class I and Class II was observed on IFN?
Positive_regulation (observed) of Gene_expression (observed) of MHC
20) Confidence 0.09 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2814860 Disease Relevance 0.33 Pain Relevance 0.20

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