INT286713

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.66
First Reported 2009
Last Reported 2010
Negated 3
Speculated 1
Reported most in Body
Documents 3
Total Number 11
Disease Relevance 2.56
Pain Relevance 0.10

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Musk) plasma membrane (Musk) kinase activity (Musk)
Anatomy Link Frequency
muscle 2
Musk (Mus musculus)
Pain Link Frequency Relevance Heat
Action potential 9 95.44 Very High Very High Very High
anesthesia 11 56.16 Quite High
imagery 9 5.00 Very Low Very Low Very Low
cytokine 2 5.00 Very Low Very Low Very Low
Inflammatory response 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Congenital Myasthenic Syndromes 198 97.04 Very High Very High Very High
Congenital Anomalies 18 96.20 Very High Very High Very High
Lower Respiratory Tract Infection 9 93.68 High High
Respiratory Failure 18 92.60 High High
Patent Ductus Arteriosus 9 87.08 High High
Scoliosis 9 86.80 High High
Muscle Weakness 18 85.60 High High
Cyanosis 9 85.40 High High
Adhesions 4 81.40 Quite High
Cognitive Disorder 9 74.08 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Thus, the abnormal function of the MuSK mutants can not be explained on the basis of an impaired interaction between agrin and MuSK through the co-receptor Lrp4.
Neg (not) Gene_expression (explained) of MuSK
1) Confidence 0.66 Published 2010 Journal Human Molecular Genetics Section Body Doc Link PMC2876883 Disease Relevance 0.32 Pain Relevance 0.06
We found that the interaction of the patient's MuSK mutants with the co-receptor of agrin Lrp4 was not affected.
Gene_expression (mutants) of MuSK
2) Confidence 0.66 Published 2010 Journal Human Molecular Genetics Section Body Doc Link PMC2876883 Disease Relevance 0.28 Pain Relevance 0
One of the mutations, c220insC resulting in frameshift, produced no MuSK expression when assayed in an expression system.
Neg (no) Gene_expression (expression) of MuSK
3) Confidence 0.59 Published 2010 Journal Human Molecular Genetics Section Body Doc Link PMC2876883 Disease Relevance 0.26 Pain Relevance 0
These mutations impair the expression and stability of MuSK, diminish agrin-dependent MuSK phosphorylation and AChR clustering, and fail to co-immunoprecipitate with Dok-7 but not with Lrp4 or Tid1.
Gene_expression (expression) of MuSK
4) Confidence 0.59 Published 2010 Journal Human Molecular Genetics Section Body Doc Link PMC2876883 Disease Relevance 0.38 Pain Relevance 0
Serum antibodies against AChR and MuSK were negative.
Neg (negative) Gene_expression (negative) of MuSK
5) Confidence 0.59 Published 2010 Journal Human Molecular Genetics Section Body Doc Link PMC2876883 Disease Relevance 0.73 Pain Relevance 0.05
To investigate the effect of the identified MUSK mutations on expression and function of MuSK we engineered the identified MUSK mutants using site-directed mutagenesis of human and mouse full-length MuSK cDNA constructs and expressed them in human heterologous cells and mouse C2C12 and MuSK?
Spec (investigate) Gene_expression (expression) of MuSK
6) Confidence 0.59 Published 2010 Journal Human Molecular Genetics Section Body Doc Link PMC2876883 Disease Relevance 0 Pain Relevance 0
These mutations impair the expression and stability of MuSK, diminish agrin-dependent MuSK phosphorylation and AChR clustering, and fail to co-immunoprecipitate with Dok-7 but not with Lrp4 or Tid1.
Gene_expression (expression) of MuSK
7) Confidence 0.59 Published 2010 Journal Human Molecular Genetics Section Body Doc Link PMC2876883 Disease Relevance 0.38 Pain Relevance 0
Expression and stability of MUSK mutants in HEK293 cells
Gene_expression (Expression) of MUSK
8) Confidence 0.59 Published 2010 Journal Human Molecular Genetics Section Body Doc Link PMC2876883 Disease Relevance 0.07 Pain Relevance 0
To investigate the effect of the identified MUSK mutations on expression and function of MuSK we engineered the identified MUSK mutants using site-directed mutagenesis of human and mouse full-length MuSK cDNA constructs and expressed them in human heterologous cells and mouse C2C12 and MuSK?
Gene_expression (expressed) of MuSK
9) Confidence 0.51 Published 2010 Journal Human Molecular Genetics Section Body Doc Link PMC2876883 Disease Relevance 0 Pain Relevance 0
Thus, muscle-specific deletion of the p38?
Gene_expression (deletion) of muscle-specific in muscle
10) Confidence 0.04 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2775956 Disease Relevance 0.15 Pain Relevance 0
Our finding that muscle-specific overexpression of a dominant negative form of p38?
Gene_expression (overexpression) of muscle-specific in muscle
11) Confidence 0.04 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2775956 Disease Relevance 0 Pain Relevance 0

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox