INT286715

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Context Info
Confidence 0.56
First Reported 2009
Last Reported 2011
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 5
Disease Relevance 2.19
Pain Relevance 0.74

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Ppargc1a) RNA binding (Ppargc1a) mitochondrion organization (Ppargc1a)
nucleus (Ppargc1a) DNA binding (Ppargc1a) transcription factor binding (Ppargc1a)
Anatomy Link Frequency
ventricle 1
Ppargc1a (Mus musculus)
Pain Link Frequency Relevance Heat
electroacupuncture 246 99.24 Very High Very High Very High
Acupuncture 30 95.52 Very High Very High Very High
cOX1 3 74.28 Quite High
Inflammation 3 39.80 Quite Low
tolerance 21 5.00 Very Low Very Low Very Low
fibrosis 10 5.00 Very Low Very Low Very Low
Neuropeptide 6 5.00 Very Low Very Low Very Low
anesthesia 4 5.00 Very Low Very Low Very Low
Central nervous system 3 5.00 Very Low Very Low Very Low
Spinal cord 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Diabetes Mellitus 42 97.52 Very High Very High Very High
Stress 15 97.04 Very High Very High Very High
Hypertrophy 9 96.64 Very High Very High Very High
Insulin Resistance 78 95.12 Very High Very High Very High
Hyperglycemia 9 89.76 High High
Obesity 36 86.56 High High
Sprains And Strains 6 80.00 Quite High
Coronary Heart Disease 13 79.36 Quite High
Hypoxia 2 61.72 Quite High
Metabolic Disorder 3 54.80 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Alternatively, the effect may reflect the posttranslational regulation of PGC-1?
Regulation (regulation) of PGC-1
1) Confidence 0.56 Published 2011 Journal Evidence-based Complementary and Alternative Medicine : eCAM Section Body Doc Link PMC2964507 Disease Relevance 0.54 Pain Relevance 0.16
positively regulate Pgc-1?
Regulation (regulate) of Pgc
2) Confidence 0.26 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2775956 Disease Relevance 0.06 Pain Relevance 0
The present study tested the hypothesis that electroacupuncture (EA) ameliorates insulin sensitivity via regulation of SIRT1/PGC-1?
Regulation (regulation) of PGC-1 associated with electroacupuncture
3) Confidence 0.25 Published 2011 Journal Evidence-based Complementary and Alternative Medicine : eCAM Section Body Doc Link PMC2964507 Disease Relevance 0.60 Pain Relevance 0.43
Collectively, these findings indicate that therapy targeting SIRT1/PGC-1?
Regulation (targeting) of PGC-1
4) Confidence 0.25 Published 2011 Journal Evidence-based Complementary and Alternative Medicine : eCAM Section Body Doc Link PMC2964507 Disease Relevance 0.81 Pain Relevance 0.15
Overall, these data support the notion that depletion of MEF2C attenuates the load-induced replication of mtDNA and likely in mitochondrial biogenesis in mice left ventricle, associated to a defect in the regulation of PGC-1?
Regulation (regulation) of PGC-1 in ventricle
5) Confidence 0.11 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2794538 Disease Relevance 0.18 Pain Relevance 0

General Comments

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