INT28673

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Context Info
Confidence 0.73
First Reported 1989
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 51
Total Number 51
Disease Relevance 34.02
Pain Relevance 3.95

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (APOB) small molecule metabolic process (APOB) endoplasmic reticulum (APOB)
enzyme binding (APOB) lipid metabolic process (APOB) extracellular space (APOB)
Anatomy Link Frequency
plasma 7
B cells 2
liver 1
external 1
bile 1
APOB (Homo sapiens)
APOB - G387A (1)
Pain Link Frequency Relevance Heat
Opioid 23 99.60 Very High Very High Very High
antagonist 98 99.32 Very High Very High Very High
interstitial cystitis 7 99.16 Very High Very High Very High
Bile 21 99.10 Very High Very High Very High
narcan 51 99.04 Very High Very High Very High
adenocard 9 96.56 Very High Very High Very High
Morphine 51 96.32 Very High Very High Very High
Inflammation 154 95.64 Very High Very High Very High
dexamethasone 3 94.68 High High
cytokine 10 94.04 High High
Disease Link Frequency Relevance Heat
Disorder Of Lipid Metabolism 988 100.00 Very High Very High Very High
Familial Combined Hyperlipidemia 254 99.64 Very High Very High Very High
Cardiovascular Disease 576 99.60 Very High Very High Very High
Dyslipidemia /

Combined Dyslipidemia

121 99.28 Very High Very High Very High
Interstitial Cystitis 7 99.16 Very High Very High Very High
INFLAMMATION 179 99.04 Very High Very High Very High
Disease 249 98.74 Very High Very High Very High
Repression 2 98.74 Very High Very High Very High
Mental Disorders 10 98.56 Very High Very High Very High
Appetite Loss 19 98.06 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
While obligate heterozygote parents of HHBL patients have half-normal plasma levels of apo B and LDL-cholesterol, obligate heterozygote parents of ABL patients have normal plasma lipoprotein profiles.
Gene_expression (levels) of apo B in plasma
1) Confidence 0.73 Published 2008 Journal Orphanet J Rare Dis Section Body Doc Link PMC2467409 Disease Relevance 0.77 Pain Relevance 0.03
This C-to-U editing (C>U) of APOB transcripts changes a glutamine codon to a premature stop codon in the intestine, giving rise to a functionally important, truncated 48 kDa protein, whereas the non-edited APOB100 is expressed in liver.
Gene_expression (expressed) of APOB100 in liver
2) Confidence 0.71 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2813293 Disease Relevance 0.17 Pain Relevance 0.17
ApoB stands for apolipoprotein B-100 and is the chief protein component constituent of the atherogenic very-low-density lipoprotein (VLDL), of intermediate-density lipoprotein (IDL) and of LDL particles, each particle including one apoB molecule.
Gene_expression (stands) of apolipoprotein B-100 associated with disorder of lipid metabolism
3) Confidence 0.66 Published 2006 Journal Biomark Insights Section Body Doc Link PMC2716782 Disease Relevance 0.86 Pain Relevance 0.03
Moreover, it is interesting that other investigators (Schaefer et al. 1994) concluded that plasma apoB values ?
Gene_expression (values) of apoB in plasma
4) Confidence 0.66 Published 2006 Journal Biomark Insights Section Body Doc Link PMC2716782 Disease Relevance 0.84 Pain Relevance 0.09
In our study, patients with prominent CVD had elevated serum apoB and Lp(a) levels and apoB/apoA-I ratio values, as well as lower serum levels of apoA-I compared to patients without prevalent CVD.
Gene_expression (levels) of apoB associated with cardiovascular disease
5) Confidence 0.66 Published 2006 Journal Biomark Insights Section Body Doc Link PMC2716782 Disease Relevance 0.81 Pain Relevance 0
One cannot discriminate, however, from the data of our study whether there is absolute lack of an effect or whether apoB levels remain eventually elevated due to counter-acting effects of overproduction of apoB, which is known to occur in HD patients (Chan et al. 1989), and a probable apoB-lowering effect of systemic inflammation and malnutrition.
Gene_expression (overproduction) of apoB associated with appetite loss and inflammation
6) Confidence 0.66 Published 2006 Journal Biomark Insights Section Body Doc Link PMC2716782 Disease Relevance 1.10 Pain Relevance 0.21
ApoB stands for apolipoprotein B-100 and is the chief protein component constituent of the atherogenic very-low-density lipoprotein (VLDL), of intermediate-density lipoprotein (IDL) and of LDL particles, each particle including one apoB molecule.
Gene_expression (stands) of ApoB associated with disorder of lipid metabolism
7) Confidence 0.66 Published 2006 Journal Biomark Insights Section Body Doc Link PMC2716782 Disease Relevance 0.86 Pain Relevance 0.03
Moreover, although in many conditions LDL cholesterol and apoB levels increase in parallel (e.g. familial hypercholesterolaemia), in ESRD patients, due to hypertriglyceridemia, malnutrition or metabolic disturbances, LDL-C levels are often phenomenically ‘normal,’ as in our study, yet apoB levels are rather elevated due to its overproduction and this results in the formation of a small, dense form of LDL (pattern B phenotype).
Gene_expression (levels) of apoB associated with appetite loss, chronic renal failure and hyperlipidemia
8) Confidence 0.66 Published 2006 Journal Biomark Insights Section Body Doc Link PMC2716782 Disease Relevance 1.12 Pain Relevance 0.14
PopApoB/A1 ?
Gene_expression (/) of ApoB
9) Confidence 0.65 Published 2008 Journal BMC Med Inform Decis Mak Section Body Doc Link PMC2601038 Disease Relevance 1.40 Pain Relevance 0
The correlations were strongest for the collagenase-extractable apo B, while no correlations were observed for the buffer-extractable intimal apo B.
Gene_expression (extractable) of apo B
10) Confidence 0.64 Published 1989 Journal Atherosclerosis Section Abstract Doc Link 2787644 Disease Relevance 0.56 Pain Relevance 0.07
There were significant correlations between total or collagenase-extractable apo B and serum cholesterol (rs = 0.39, P less than 0.01), serum triglycerides (rs = 0.33, P less than 0.05), LDL cholesterol (rs = 0.33, P less than 0.05) and serum apo B (rs = 0.37, P less than 0.05).
Gene_expression (extractable) of apo B
11) Confidence 0.64 Published 1989 Journal Atherosclerosis Section Abstract Doc Link 2787644 Disease Relevance 0.42 Pain Relevance 0
The correlations were strongest for the collagenase-extractable apo B, while no correlations were observed for the buffer-extractable intimal apo B.
Gene_expression (strongest) of apo B
12) Confidence 0.64 Published 1989 Journal Atherosclerosis Section Abstract Doc Link 2787644 Disease Relevance 0.56 Pain Relevance 0.07
There were significant correlations between total or collagenase-extractable apo B and serum cholesterol (rs = 0.39, P less than 0.01), serum triglycerides (rs = 0.33, P less than 0.05), LDL cholesterol (rs = 0.33, P less than 0.05) and serum apo B (rs = 0.37, P less than 0.05).
Gene_expression (extractable) of apo B
13) Confidence 0.64 Published 1989 Journal Atherosclerosis Section Abstract Doc Link 2787644 Disease Relevance 0.53 Pain Relevance 0.06
In this respect, APOB48 transcripts are protected from NMD by the C>U editing machinery, which allows for the expression of the truncated APOB form [47], [48], [49].
Gene_expression (expression) of APOB
14) Confidence 0.62 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2813293 Disease Relevance 0 Pain Relevance 0.04
Cardiovascular risk was found to be better explained by concentrations of LDL particles or plasma levels of apolipoprotein B (ApoB), than by LDL-C (Berneis et al 2002; Blake et al 2002; Rizzo et al 2007).
Gene_expression (levels) of apolipoprotein B in plasma associated with disorder of lipid metabolism
15) Confidence 0.60 Published 2008 Journal Vascular Health and Risk Management Section Body Doc Link PMC2464751 Disease Relevance 0.80 Pain Relevance 0
Such dyslipidemia is also characterized by increased levels of atherogenic lipoproteins including, elevated apo B, and small, dense LDL and HDL particles (Tchernof et al 1996).
Gene_expression (levels) of apo B associated with disorder of lipid metabolism
16) Confidence 0.60 Published 2008 Journal Vascular Health and Risk Management Section Body Doc Link PMC2464751 Disease Relevance 1.62 Pain Relevance 0
Cardiovascular risk was found to be better explained by concentrations of LDL particles or plasma levels of apolipoprotein B (ApoB), than by LDL-C (Berneis et al 2002; Blake et al 2002; Rizzo et al 2007).
Gene_expression (levels) of ApoB in plasma associated with disorder of lipid metabolism
17) Confidence 0.60 Published 2008 Journal Vascular Health and Risk Management Section Body Doc Link PMC2464751 Disease Relevance 0.80 Pain Relevance 0
MTP acts as a chaperone that facilitates the transfer of lipids onto apo B.
Gene_expression (transfer) of apo B
18) Confidence 0.57 Published 2008 Journal Orphanet J Rare Dis Section Body Doc Link PMC2467409 Disease Relevance 0.25 Pain Relevance 0
Collectively, ApoE polymorphism with primary influence on total cholesterol, LDL-C, and apoB levels does not seem to provide a major biological linkage between the pathogenesis of osteoporosis and CVD.
Gene_expression (levels) of apoB associated with cardiovascular disease, osteoporosis and disorder of lipid metabolism
19) Confidence 0.52 Published 2006 Journal Osteoporos Int Section Body Doc Link PMC1820757 Disease Relevance 0.91 Pain Relevance 0
ApoB/A1I ?
Gene_expression (/) of ApoB
20) Confidence 0.50 Published 2008 Journal BMC Med Inform Decis Mak Section Body Doc Link PMC2601038 Disease Relevance 1.44 Pain Relevance 0

General Comments

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