INT28674

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Context Info
Confidence 0.40
First Reported 1989
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 2.36
Pain Relevance 1.16

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell proliferation (Pla2g1b) extracellular space (Pla2g1b) extracellular region (Pla2g1b)
response to stress (Pla2g1b)
Pla2g1b (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 6 98.92 Very High Very High Very High
corticosteroid 60 98.70 Very High Very High Very High
Analgesic 4 98.26 Very High Very High Very High
Inflammatory mediators 5 97.76 Very High Very High Very High
adenocard 5 94.00 High High
bradykinin 2 88.52 High High
Inflammatory response 1 84.32 Quite High
Somatostatin 2 81.20 Quite High
Potency 1 69.40 Quite High
Hyperalgesia 1 66.80 Quite High
Disease Link Frequency Relevance Heat
INFLAMMATION 14 98.92 Very High Very High Very High
Pressure And Volume Under Development 20 96.20 Very High Very High Very High
Injury 10 95.48 Very High Very High Very High
Pancreatitis 68 95.36 Very High Very High Very High
Retina Disease 25 78.28 Quite High
Hyperamylasemia 12 78.12 Quite High
Hyperalgesia 1 66.80 Quite High
Stress 3 49.68 Quite Low
Sprains And Strains 5 42.64 Quite Low
Gliosis 7 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
From these results, it is suggested that the analgesic effect of EB-382 in inflammation is exerted through its direct peripheral action, and inhibition of prostaglandin biosynthesis via phospholipase A2, rather than cyclooxygenase.
Negative_regulation (inhibition) of Gene_expression (biosynthesis) of phospholipase A2 associated with inflammation and analgesic
1) Confidence 0.40 Published 1989 Journal Chem. Pharm. Bull. Section Abstract Doc Link 2787705 Disease Relevance 0.30 Pain Relevance 0.53
The selective inhibitors of phospholipase A2, 4-bromophenacyl bromide (300 µM), and of cyclooxygenase, indomethacin (10 µM), prevented the swelling of Müller cells from Dp71-null mice (Fig. 5C; 103.3±2.1%, n?
Negative_regulation (inhibitors) of Gene_expression (selective) of phospholipase A2 associated with pressure and volume under development
2) Confidence 0.13 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2754330 Disease Relevance 0.81 Pain Relevance 0.30
It has been shown that corticosteroid is able to increase activity of C1-antiprotease inhibitor [14], decrease synthesis of phospholipase A2 [15], and suppress cellular and humoral responses.
Negative_regulation (decrease) of Gene_expression (synthesis) of phospholipase A2 associated with corticosteroid
3) Confidence 0.01 Published 2008 Journal BMC Gastroenterol Section Body Doc Link PMC2258301 Disease Relevance 1.25 Pain Relevance 0.34

General Comments

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