INT286753

Context Info Confidence 0.09 First Reported 2009 Last Reported 2009 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 2 Disease Relevance 2.82 Pain Relevance 0.31

cytosol (Apaf1) Golgi apparatus (Apaf1) nucleus (Apaf1) intracellular (Apaf1) cytoplasm (Apaf1)

Apaf1 (Mus musculus)

Pain Link Frequency Relevance Heat Inflammation 32 86.40 Pain 2 5.00

Disease Link Frequency Relevance Heat Apoptosis 2 99.96 Cancer 142 96.72 Non-small-cell Lung Cancer 2 93.68 Autoimmune Disease 6 88.64 INFLAMMATION 32 86.40 Metastasis 2 79.68 Lung Cancer 186 77.04 Malignant Neoplastic Disease 16 5.00 Hypoxia 8 5.00 Targeted Disruption 6 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

The effect of TUSC2 on chemosensitivity was associated with down-regulation of MDM2, accumulation of p53, and activation of the Apaf-1 apoptotic pathway [22].

Negative_regulation (down) of Positive_regulation (activation) of Apaf-1 associated with apoptosis

1) Confidence 0.09 Published 2009 Journal Mol Cancer Section Body Doc Link PMC2776015 Disease Relevance 1.41 Pain Relevance 0.15

The effect of TUSC2 on chemosensitivity was associated with down-regulation of MDM2, accumulation of p53, and activation of the Apaf-1 apoptotic pathway [22].

Negative_regulation (regulation) of Positive_regulation (activation) of Apaf-1 associated with apoptosis

2) Confidence 0.09 Published 2009 Journal Mol Cancer Section Body Doc Link PMC2776015 Disease Relevance 1.41 Pain Relevance 0.15

General Comments

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