INT28679

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Context Info
Confidence 0.60
First Reported 1989
Last Reported 2011
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 5
Disease Relevance 2.75
Pain Relevance 1.53

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Tnfsf13b) extracellular region (Tnfsf13b) plasma membrane (Tnfsf13b)
Anatomy Link Frequency
synovial fluid 1
epidermal cells 1
immature B cells 1
B cell 1
thymocyte 1
Tnfsf13b (Mus musculus)
Pain Link Frequency Relevance Heat
lidocaine 16 99.82 Very High Very High Very High
Inflammation 50 91.20 High High
cytokine 14 86.32 High High
chemokine 3 81.88 Quite High
rheumatoid arthritis 69 81.84 Quite High
anesthesia 3 61.36 Quite High
spinal inflammation 1 48.84 Quite Low
Arthritis 13 5.00 Very Low Very Low Very Low
Chronic pancreatitis 4 5.00 Very Low Very Low Very Low
Inflammatory response 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Necrosis 5 96.64 Very High Very High Very High
Aging 3 96.60 Very High Very High Very High
Cancer 4 96.28 Very High Very High Very High
Targeted Disruption 46 93.80 High High
INFLAMMATION 52 91.20 High High
Syndrome 79 90.76 High High
Salivary Gland Disease 20 87.52 High High
Autoimmune Disease 16 86.80 High High
Systemic Lupus Erythematosus 11 84.32 Quite High
Rheumatoid Arthritis 69 81.84 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Lidocaine-induced inhibition of the production of interleukin 1-like epidermal cell-derived thymocyte activating factor.
Gene_expression (production) of epidermal cell-derived thymocyte activating factor in thymocyte associated with lidocaine
1) Confidence 0.60 Published 1989 Journal J. Invest. Dermatol. Section Title Doc Link 2787824 Disease Relevance 0 Pain Relevance 0.70
For the purpose of investigating the influence of the cationic anesthetic, lidocaine, on the production of epidermal cell-derived thymocyte activating factor (ETAF), murine epidermal cells were incubated for 1 h with 0.02-6 mg/ml lidocaine, washed, and incubated for an additional 23 h.
Gene_expression (production) of epidermal cell-derived thymocyte activating factor in epidermal cells associated with lidocaine
2) Confidence 0.60 Published 1989 Journal J. Invest. Dermatol. Section Abstract Doc Link 2787824 Disease Relevance 0 Pain Relevance 0.40
The discrepancy with the complete B cell depletion observed in peripheral blood in nearly all patients might be explained by the expression of protective factors in the tissue, such as BLyS25 and CD55 (decay-accelerating factor (DAF)),26 as well as the requirement for B cells to access the circulation for efficient depletion.
Gene_expression (expression) of BLyS25 in B cell
3) Confidence 0.38 Published 2008 Journal Annals of the Rheumatic Diseases Section Body Doc Link PMC2564787 Disease Relevance 0.45 Pain Relevance 0.31
family member B lymphocyte stimulator (BLyS, also called Baff) has also recently been detected at high levels in rheumatoid synovial fluid, suggesting that this prosurvival factor can also be locally produced in inflamed joints [57].
Gene_expression (detected) of BLyS in synovial fluid
4) Confidence 0.28 Published 2003 Journal Arthritis Res Ther Section Body Doc Link PMC2833442 Disease Relevance 0.39 Pain Relevance 0.12
BAFF is produced by myeloid cells and acts to induce the polyclonal maturation of resting immature B cells to resting mature B cells without stimulating proliferation [75].
Gene_expression (produced) of BAFF in immature B cells
5) Confidence 0.24 Published 2011 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC3018660 Disease Relevance 1.91 Pain Relevance 0

General Comments

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