INT286803

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Context Info
Confidence 0.27
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 5
Disease Relevance 2.73
Pain Relevance 1.55

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
spinal 1
spinal cord 1
astrocyte 1
neural 1
Neurog2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Neuropathic pain 22 99.52 Very High Very High Very High
Spinal cord 199 98.62 Very High Very High Very High
allodynia 30 98.32 Very High Very High Very High
Thermal hyperalgesia 12 91.56 High High
Serotonin 36 91.52 High High
Pain 18 89.96 High High
Inflammatory response 4 76.24 Quite High
hyperpathia 4 73.20 Quite High
Inflammation 4 72.60 Quite High
agonist 7 53.60 Quite High
Disease Link Frequency Relevance Heat
Neuropathic Pain 52 99.52 Very High Very High Very High
Acquired Immune Deficiency Syndrome Or Hiv Infection 4 99.14 Very High Very High Very High
Spinal Cord Compression 32 98.86 Very High Very High Very High
Injury 190 98.22 Very High Very High Very High
Hyperalgesia 16 91.56 High High
Spinal Cord Injury 135 85.96 High High
INFLAMMATION 8 75.88 Quite High
Syndrome 9 74.60 Quite High
Pain 15 74.20 Quite High
Fibrosis 4 71.04 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We used four types of flap bearing HIV-1 derived lentiviral vectors [33], either expressing GFP or human neurogenin-2 cDNA under control of the house keeping promoter of the phosphoglycerate kinase promoter (PGK).
Gene_expression (expressing) of neurogenin-2 associated with acquired immune deficiency syndrome or hiv infection
1) Confidence 0.27 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3012721 Disease Relevance 0.16 Pain Relevance 0.03
With the objective of translation to clinics we have chosen a paradigm of delayed grafting, i.e., one week after lesion, in a severe model of spinal cord compression in adult rats. hENPs were either naïve or engineered to express Neurogenin 2 (Ngn2).
Gene_expression (express) of Neurogenin 2 in spinal cord associated with spinal cord
2) Confidence 0.27 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC3012721 Disease Relevance 0.40 Pain Relevance 0.20
Given the clear functional improvement observed in spinal cord injured-rat transplanted with human neural progenitors engineered to express Neurogenin-2, it is very important to elucidate the mechanisms of action that underlie this positive outcomes.
Gene_expression (express) of Neurogenin-2 in neural associated with spinal cord
3) Confidence 0.27 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3012721 Disease Relevance 0.49 Pain Relevance 0.28
Others had shown that transplantation of rat adult neural stem cells in a rodent model of spinal weight-drop injury improved functional recovery but also increased neuropathic pain whereas previous cells transduction with neurogenin-2 prevented astrocytic differentiation and allodynia [12].
Gene_expression (transduction) of neurogenin-2 in spinal associated with allodynia, injury and neuropathic pain
4) Confidence 0.24 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3012721 Disease Relevance 0.99 Pain Relevance 0.38
These adverse side effects correlated with the differentiation of the transplanted NSCs into astrocytes, and were prevented by the suppression of astrocyte generation by overexpression of the transcription factor neurogenin-2 in the transplanted NSCs [15].
Gene_expression (overexpression) of transcription factor neurogenin-2 in astrocyte
5) Confidence 0.03 Published 2008 Journal J Biol Section Body Doc Link PMC2776404 Disease Relevance 0.69 Pain Relevance 0.66

General Comments

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