INT28689

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Context Info
Confidence 0.23
First Reported 1989
Last Reported 2008
Negated 0
Speculated 0
Reported most in Abstract
Documents 4
Total Number 4
Disease Relevance 1.28
Pain Relevance 0.85

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (C3) extracellular space (C3) extracellular region (C3)
C3 (Homo sapiens)
Pain Link Frequency Relevance Heat
anesthesia 2 98.88 Very High Very High Very High
Morphine 5 92.32 High High
Inflammation 12 90.20 High High
Angina 2 83.52 Quite High
cytokine 3 79.16 Quite High
opiate 1 77.16 Quite High
cva 1 23.52 Low Low
rheumatoid arthritis 6 5.00 Very Low Very Low Very Low
ischemia 3 5.00 Very Low Very Low Very Low
Inflammatory response 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Adhesions 3 96.36 Very High Very High Very High
Syndrome 7 95.64 Very High Very High Very High
INFLAMMATION 14 90.20 High High
Targeted Disruption 2 89.76 High High
Neurodegenerative Disease 1 83.08 Quite High
Cv General 3 Under Development 3 75.56 Quite High
Coronary Artery Disease 5 75.28 Quite High
Yang Deficiency 1 57.60 Quite High
Bites And Stings 3 25.92 Quite Low
Salivary Gland Disease 22 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Inhibition of IL-1beta mediated C3 promoter activation by the dominant negative mutant of p38-alpha mitogen-activated protein kinase suggests that IL-1beta induces C3 expression through the activation of C/EBP.
Negative_regulation (Inhibition) of Positive_regulation (activation) of C3
1) Confidence 0.23 Published 2008 Journal J Neuroimmune Pharmacol Section Abstract Doc Link 18247123 Disease Relevance 0.17 Pain Relevance 0.55
The effect of IxAC proteins may therefore be explained by a decreased stability of C3 convertase due to blocking of properdin.
Negative_regulation (decreased) of Positive_regulation (stability) of C3
2) Confidence 0.10 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2151134 Disease Relevance 0.09 Pain Relevance 0
In both groups of patients the serum concentrations of C3, C4, C5, and C1 inhibitor were significantly affected by the treatments (p < 0.001), decreased immediately after onset of anesthesia, were minimal during surgery, and increased thereafter.
Negative_regulation (decreased) of Positive_regulation (concentrations) of C3 associated with anesthesia
3) Confidence 0.06 Published 1999 Journal Pediatr Cardiol Section Abstract Doc Link 9986887 Disease Relevance 0.17 Pain Relevance 0.14
After the treatment with Kuo Guan No 1, the increased level of C3 in serum in QYXXY group was lowered down to that of the controls (P greater than 0.05).
Negative_regulation (lowered) of Positive_regulation (increased) of C3
4) Confidence 0.05 Published 1989 Journal Zhong Xi Yi Jie He Za Zhi Section Abstract Doc Link 2788037 Disease Relevance 0.84 Pain Relevance 0.16

General Comments

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