INT286953

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Context Info
Confidence 0.21
First Reported 2009
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 8
Total Number 9
Disease Relevance 1.74
Pain Relevance 0.27

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

molecular_function (TNXA) cellular_component (TNXA) biological_process (TNXA)
Anatomy Link Frequency
plasma 3
TNXA (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 8 86.64 High High
aspirin 17 85.24 High High
cva 68 67.16 Quite High
Parenteral administration 1 28.08 Quite Low
antagonist 13 5.00 Very Low Very Low Very Low
Regional anesthesia 8 5.00 Very Low Very Low Very Low
Bioavailability 4 5.00 Very Low Very Low Very Low
Angina 2 5.00 Very Low Very Low Very Low
Lasting pain 1 5.00 Very Low Very Low Very Low
abdominal pain 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Heparin-induced Thrombocytopenia 7 97.44 Very High Very High Very High
INFLAMMATION 8 86.64 High High
Hemorrhage 67 81.04 Quite High
Syndrome 8 75.68 Quite High
Thrombosis Related Under Development 64 75.32 Quite High
Disease 12 72.56 Quite High
Cv General 3 Under Development 23 67.16 Quite High
Acute Coronary Syndrome 31 58.16 Quite High
Thromboembolism 8 55.76 Quite High
Thrombophilia 16 52.28 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Fondaparinux, a pentasaccharide, is a synthetic indirect inhibitor of Factor Xa (FXa).
Gene_expression (synthetic) of Xa
1) Confidence 0.21 Published 2010 Journal Vascular Health and Risk Management Section Body Doc Link PMC2879296 Disease Relevance 1.01 Pain Relevance 0.03
Spearman correlation coefficient (r) was calculated for correlation between the TEG parameters and antiXa.
Gene_expression (parameters) of antiXa
2) Confidence 0.09 Published 2009 Journal Thromb J Section Body Doc Link PMC2777119 Disease Relevance 0.07 Pain Relevance 0.06
Samples were analyzed for antiXa level and the TEG parameters.


Spec (analyzed) Gene_expression (level) of antiXa
3) Confidence 0.09 Published 2009 Journal Thromb J Section Body Doc Link PMC2777119 Disease Relevance 0.09 Pain Relevance 0.09
Since the dose of dalteparin applied in this study was according to established guidelines by the manufacturer, none of the subjects reached supra-therapeutic levels of antiXa.
Gene_expression (levels) of antiXa
4) Confidence 0.08 Published 2009 Journal Thromb J Section Body Doc Link PMC2777119 Disease Relevance 0.20 Pain Relevance 0
The sensitivity and specificity of each TEG parameter for plasma levels of antiXa in the therapeutic range of 0.5 - 1.0 U/ml were calculated.
Gene_expression (levels) of antiXa in plasma
5) Confidence 0.08 Published 2009 Journal Thromb J Section Body Doc Link PMC2777119 Disease Relevance 0.06 Pain Relevance 0.06
The sensitivity and specificity of each TEG parameter and TDR for plasma levels of antiXa in the therapeutic range was calculated using the cut off point of 13 mm for R, 66° for alpha, 58 mm for MA and 10 for TDR (Figure 1).
Gene_expression (levels) of antiXa in plasma
6) Confidence 0.08 Published 2009 Journal Thromb J Section Body Doc Link PMC2777119 Disease Relevance 0 Pain Relevance 0
The sensitivity and specificity of the TEG parameters for plasma levels of antiXa in the therapeutic range of 0.5 - 1.0 U/ml were calculated.


Gene_expression (levels) of antiXa in plasma
7) Confidence 0.08 Published 2009 Journal Thromb J Section Abstract Doc Link PMC2777119 Disease Relevance 0.17 Pain Relevance 0.03
In addition none of the subjects had sub-therapeutic levels of antiXa in the time intervals chosen in this study.
Gene_expression (levels) of antiXa
8) Confidence 0.08 Published 2009 Journal Thromb J Section Body Doc Link PMC2777119 Disease Relevance 0.15 Pain Relevance 0
In this study we have demonstrated a strong correlation between all basic TEG parameters and antiXa levels in healthy volunteers receiving a single dose subcutaneous injection of dalteparin.
Gene_expression (levels) of antiXa
9) Confidence 0.08 Published 2009 Journal Thromb J Section Body Doc Link PMC2777119 Disease Relevance 0 Pain Relevance 0

General Comments

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