INT286965

Context Info Confidence 0.27 First Reported 2009 Last Reported 2009 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 3 Disease Relevance 1.84 Pain Relevance 0.19

cytoplasm (STAT3, FOXP3) nucleus (STAT3, FOXP3) nucleoplasm (STAT3) intracellular (FOXP3) embryo development (FOXP3) DNA binding (STAT3)

STAT3 (Homo sapiens) FOXP3 (Homo sapiens)

Pain Link Frequency Relevance Heat dexamethasone 9 74.56 cytokine 9 72.96 Inflammation 3 70.72 Inflammatory response 3 53.28 Central nervous system 21 52.04 imagery 15 5.00 anesthesia 6 5.00

Disease Link Frequency Relevance Heat Glioma 102 92.60 Cancer 138 89.24 INFLAMMATION 6 70.72 Glioblastoma 57 52.96 Anaplastic Astrocytoma 6 51.96 Malignant Neoplastic Disease 9 50.28 Apoptosis 3 45.48 Brain Tumor 6 33.24 Recurrence 3 11.28 Necrosis 12 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

More specifically, IL-2 has been shown to regulate FoxP3 expression in human CD4+CD25+ Tregs by inducing STAT-3 binding of the first intron of the FoxP3 gene [20].

STAT-3 Binding (binding) of FoxP3 gene

1) Confidence 0.27 Published 2009 Journal J Transl Med Section Body Doc Link PMC2777138 Disease Relevance 0.60 Pain Relevance 0.06

Furthermore, we selected this particular marker of immune suppression because IL-2 has been shown to regulate FoxP3 expression in human CD4+CD25+ Tregs [48] by inducing STAT-3 binding of the first intron of the FoxP3 gene [20] and because STAT-3 inhibitors have been shown to inhibit Tregs [26,36].

STAT-3 Binding (binding) of FoxP3 gene

2) Confidence 0.27 Published 2009 Journal J Transl Med Section Body Doc Link PMC2777138 Disease Relevance 0.49 Pain Relevance 0.06

To evaluate whether the percent of PBMCs displaying p-STAT-3 correlated with immune suppression, we tested for a correlation between the percent of PBMCs displaying p-STAT-3 and the fraction of enhanced Tregs in the systemic circulation [35] especially since p-STAT-3 binds to the first intron of the FoxP3 gene [20] and because STAT-3 inhibitors have been shown to inhibit Tregs [26,36].

STAT-3 Binding (binds) of FoxP3 gene

3) Confidence 0.24 Published 2009 Journal J Transl Med Section Body Doc Link PMC2777138 Disease Relevance 0.75 Pain Relevance 0.06

General Comments

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