INT286967

Context Info Confidence 0.35 First Reported 2009 Last Reported 2009 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 0.44 Pain Relevance 0.04

cytoplasm (STAT3, FOXP3) nucleus (STAT3, FOXP3) nucleoplasm (STAT3) intracellular (FOXP3) embryo development (FOXP3) DNA binding (STAT3)

STAT3 (Homo sapiens) FOXP3 (Homo sapiens)

Pain Link Frequency Relevance Heat cytokine 3 75.68 Inflammatory response 1 49.60 Central nervous system 7 5.00 imagery 5 5.00 dexamethasone 3 5.00 anesthesia 2 5.00 Inflammation 1 5.00

Disease Link Frequency Relevance Heat Glioma 34 95.32 Cancer 46 77.12 INFLAMMATION 2 49.60 Recurrence 1 7.60 Glioblastoma 19 5.00 Necrosis 4 5.00 Malignant Neoplastic Disease 3 5.00 Anaplastic Astrocytoma 2 5.00 Disease 2 5.00 Brain Tumor 2 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Furthermore, we selected this particular marker of immune suppression because IL-2 has been shown to regulate FoxP3 expression in human CD4+CD25+ Tregs [48] by inducing STAT-3 binding of the first intron of the FoxP3 gene [20] and because STAT-3 inhibitors have been shown to inhibit Tregs [26,36].

Positive_regulation (inducing) of STAT-3 Regulation (regulate) of Gene_expression (expression) of FoxP3

1) Confidence 0.35 Published 2009 Journal J Transl Med Section Body Doc Link PMC2777138 Disease Relevance 0.44 Pain Relevance 0.04

General Comments

This test has worked.