INT286969

Context Info Confidence 0.04 First Reported 2009 Last Reported 2009 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 2 Disease Relevance 1.05 Pain Relevance 0.10

intracellular (FOXP3) embryo development (FOXP3) protein complex (FOXP3) cytoplasm (FOXP3) cell-cell signaling (IL2) extracellular space (IL2)

IL2 (Homo sapiens) FOXP3 (Homo sapiens)

Pain Link Frequency Relevance Heat cytokine 6 76.60 Inflammation 2 63.52 Inflammatory response 2 45.68 Central nervous system 14 5.00 imagery 10 5.00 dexamethasone 6 5.00 anesthesia 4 5.00

Disease Link Frequency Relevance Heat Glioma 68 96.24 Cancer 92 92.68 INFLAMMATION 4 63.52 Glioblastoma 38 56.40 Anaplastic Astrocytoma 4 55.40 Malignant Neoplastic Disease 6 53.72 Apoptosis 2 48.92 Brain Tumor 4 36.68 Necrosis 8 5.00 Disease 4 5.00

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Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Furthermore, we selected this particular marker of immune suppression because IL-2 has been shown to regulate FoxP3 expression in human CD4+CD25+ Tregs [48] by inducing STAT-3 binding of the first intron of the FoxP3 gene [20] and because STAT-3 inhibitors have been shown to inhibit Tregs [26,36].

IL-2 Regulation (regulate) of Gene_expression (expression) of FoxP3

1) Confidence 0.04 Published 2009 Journal J Transl Med Section Body Doc Link PMC2777138 Disease Relevance 0.44 Pain Relevance 0.04

More specifically, IL-2 has been shown to regulate FoxP3 expression in human CD4+CD25+ Tregs by inducing STAT-3 binding of the first intron of the FoxP3 gene [20].

IL-2 Regulation (regulate) of Gene_expression (expression) of FoxP3

2) Confidence 0.02 Published 2009 Journal J Transl Med Section Body Doc Link PMC2777138 Disease Relevance 0.60 Pain Relevance 0.06

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