INT286970

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Context Info
Confidence 0.24
First Reported 2009
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 1.04
Pain Relevance 0.13

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

growth (FOXP3) nucleus (FOXP3) intracellular (FOXP3)
embryo development (FOXP3) protein complex (FOXP3) cytoplasm (FOXP3)
FOXP3 (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 6 72.68 Quite High
Inflammation 2 70.72 Quite High
Inflammatory response 2 53.28 Quite High
Central nervous system 14 5.00 Very Low Very Low Very Low
imagery 10 5.00 Very Low Very Low Very Low
dexamethasone 6 5.00 Very Low Very Low Very Low
anesthesia 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Glioma 68 92.32 High High
Cancer 92 88.96 High High
INFLAMMATION 4 70.72 Quite High
Glioblastoma 38 52.68 Quite High
Anaplastic Astrocytoma 4 51.68 Quite High
Malignant Neoplastic Disease 6 50.00 Quite Low
Apoptosis 2 45.20 Quite Low
Brain Tumor 4 32.96 Quite Low
Recurrence 2 11.28 Low Low
Necrosis 8 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Furthermore, we selected this particular marker of immune suppression because IL-2 has been shown to regulate FoxP3 expression in human CD4+CD25+ Tregs [48] by inducing STAT-3 binding of the first intron of the FoxP3 gene [20] and because STAT-3 inhibitors have been shown to inhibit Tregs [26,36].
FoxP3 gene Binding (binding) of
1) Confidence 0.24 Published 2009 Journal J Transl Med Section Body Doc Link PMC2777138 Disease Relevance 0.49 Pain Relevance 0.06
More specifically, IL-2 has been shown to regulate FoxP3 expression in human CD4+CD25+ Tregs by inducing STAT-3 binding of the first intron of the FoxP3 gene [20].
FoxP3 gene Binding (binding) of
2) Confidence 0.24 Published 2009 Journal J Transl Med Section Body Doc Link PMC2777138 Disease Relevance 0.55 Pain Relevance 0.06

General Comments

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