INT286971

Context Info Confidence 0.32 First Reported 2009 Last Reported 2009 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 0.57 Pain Relevance 0.09

growth (FOXP3) nucleus (FOXP3) intracellular (FOXP3) embryo development (FOXP3) protein complex (FOXP3) cytoplasm (FOXP3)

FOXP3 (Homo sapiens)

Pain Link Frequency Relevance Heat cytokine 3 98.92 dexamethasone 3 26.00 Central nervous system 7 5.00 imagery 5 5.00 anesthesia 2 5.00 Inflammation 1 5.00 Inflammatory response 1 5.00

Disease Link Frequency Relevance Heat Cancer 46 98.24 Glioma 34 64.64 Glioblastoma 19 5.00 Necrosis 4 5.00 Malignant Neoplastic Disease 3 5.00 Anaplastic Astrocytoma 2 5.00 Disease 2 5.00 INFLAMMATION 2 5.00 Brain Tumor 2 5.00 Metastasis 1 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Tumor-associated Tregs express the IL-23 receptor, which activates STAT-3 in this cell type, leading to upregulation of the Treg-specific transcription factor FoxP3 and the immunosuppressive cytokine IL-10 [47].

Positive_regulation (leading) of Positive_regulation (upregulation) of FoxP3 associated with cancer and cytokine

1) Confidence 0.32 Published 2009 Journal J Transl Med Section Body Doc Link PMC2777138 Disease Relevance 0.57 Pain Relevance 0.09

General Comments

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