INT28698

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Context Info
Confidence 0.64
First Reported 1988
Last Reported 2006
Negated 0
Speculated 2
Reported most in Abstract
Documents 13
Total Number 17
Disease Relevance 9.50
Pain Relevance 2.38

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (F7) extracellular space (F7) extracellular region (F7)
Anatomy Link Frequency
blood 3
fat 3
heart 2
plasma 1
F7 (Mus musculus)
Pain Link Frequency Relevance Heat
cva 117 99.16 Very High Very High Very High
Angina 36 96.04 Very High Very High Very High
Central nervous system 3 11.40 Low Low
anesthesia 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Hemorrhage 297 99.16 Very High Very High Very High
Coronary Artery Disease 30 98.54 Very High Very High Very High
Coronary Heart Disease 6 97.32 Very High Very High Very High
Myocardial Infarction 37 96.92 Very High Very High Very High
Increased Venous Pressure Under Development 7 96.40 Very High Very High Very High
Cv General 3 Under Development 70 96.04 Very High Very High Very High
Stable Angina Pectoris 14 88.48 High High
Adult Respiratory Distress Syndrome 9 86.16 High High
Multiple Organ Failure 3 84.56 Quite High
Coagulation Disorder 44 82.80 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The clinical implication is debatable because FVII activation was not accompanied by an increase in plasma F1+2 concentrations in patients with severe atherosclerosis.
Positive_regulation (activation) of FVII in plasma associated with increased venous pressure under development
1) Confidence 0.64 Published 2000 Journal Arterioscler. Thromb. Vasc. Biol. Section Abstract Doc Link 11073858 Disease Relevance 0.36 Pain Relevance 0.13
Studies in healthy subjects showed that blood coagulation factor VII (FVII) is activated postprandially after consumption of high-fat meals, but accompanying thrombin formation has not been demonstrated.
Positive_regulation (activated) of coagulation factor VII in fat
2) Confidence 0.64 Published 2000 Journal Arterioscler. Thromb. Vasc. Biol. Section Abstract Doc Link 11073858 Disease Relevance 0.36 Pain Relevance 0.14
Our findings confirm that high-fat meals cause immediate activation of FVII.
Positive_regulation (activation) of FVII in fat
3) Confidence 0.64 Published 2000 Journal Arterioscler. Thromb. Vasc. Biol. Section Abstract Doc Link 11073858 Disease Relevance 0.27 Pain Relevance 0.14
Studies in healthy subjects showed that blood coagulation factor VII (FVII) is activated postprandially after consumption of high-fat meals, but accompanying thrombin formation has not been demonstrated.
Positive_regulation (activated) of FVII in fat
4) Confidence 0.64 Published 2000 Journal Arterioscler. Thromb. Vasc. Biol. Section Abstract Doc Link 11073858 Disease Relevance 0.36 Pain Relevance 0.14
Venous blood samples were collected at 8:15 AM (fasting), 12:30 PM, 2:00 PM, 3:30 PM, and 4:45 PM and analyzed for triglycerides, activated FVII (FVIIa), FVII protein concentration (FVII:Ag), prothrombin fragment 1+2 (F1+2), and soluble fibrin.
Spec (analyzed) Positive_regulation (activated) of FVII in blood
5) Confidence 0.64 Published 2000 Journal Arterioscler. Thromb. Vasc. Biol. Section Abstract Doc Link 11073858 Disease Relevance 0.40 Pain Relevance 0.16
This report describes studies on the activation of coagulation factor VII (FVII) and the inhibition of the extrinsic coagulation pathway in acute ischaemic heart disease.
Positive_regulation (activation) of FVII in heart associated with coronary heart disease
6) Confidence 0.57 Published 1989 Journal Br. J. Haematol. Section Abstract Doc Link 2788454 Disease Relevance 0.37 Pain Relevance 0
This report describes studies on the activation of coagulation factor VII (FVII) and the inhibition of the extrinsic coagulation pathway in acute ischaemic heart disease.
Positive_regulation (activation) of coagulation factor VII in heart associated with coronary heart disease
7) Confidence 0.57 Published 1989 Journal Br. J. Haematol. Section Abstract Doc Link 2788454 Disease Relevance 0.37 Pain Relevance 0
This study underlines the important positive contribution of FVIIc to IHD and to the prognosis of its thrombotic acute events, and shows that the increase in FVII activity is associated with an increase of a thrombotic marker (thrombin-antithrombin).
Positive_regulation (increase) of FVII associated with coronary artery disease
8) Confidence 0.55 Published 1988 Journal Thromb. Res. Section Abstract Doc Link 3187958 Disease Relevance 1.12 Pain Relevance 0.28
Further studies are needed to evaluate if FVII activation is the cause or the consequence of the thrombotic processes.
Positive_regulation (activation) of FVII
9) Confidence 0.55 Published 1988 Journal Thromb. Res. Section Abstract Doc Link 3187958 Disease Relevance 0.90 Pain Relevance 0.26
FVIIag did not vary between groups and controls, implicating a progressive activation of FVII.
Positive_regulation (activation) of FVII
10) Confidence 0.55 Published 1988 Journal Thromb. Res. Section Abstract Doc Link 3187958 Disease Relevance 1.30 Pain Relevance 0.34
In patients with coronary atherosclerosis, the arterial intima is supposed to present more tissue factor, the cofactor of FVII, to circulating blood; therefore, thrombin formation in response to FVII activation is more likely to occur in such patients.
Positive_regulation (activation) of FVII in blood associated with coronary artery disease
11) Confidence 0.47 Published 2000 Journal Arterioscler. Thromb. Vasc. Biol. Section Abstract Doc Link 11073858 Disease Relevance 0.42 Pain Relevance 0.16
Venous blood samples were collected at 8:15 AM (fasting), 12:30 PM, 2:00 PM, 3:30 PM, and 4:45 PM and analyzed for triglycerides, activated FVII (FVIIa), FVII protein concentration (FVII:Ag), prothrombin fragment 1+2 (F1+2), and soluble fibrin.
Spec (analyzed) Positive_regulation (activated) of FVII in blood
12) Confidence 0.43 Published 2000 Journal Arterioscler. Thromb. Vasc. Biol. Section Abstract Doc Link 11073858 Disease Relevance 0.40 Pain Relevance 0.16
The concentrations of FVII:C and FVII:Ag were not modified as compared with baseline values.
Positive_regulation (concentrations) of FVII
13) Confidence 0.04 Published 2003 Journal Br. J. Haematol. Section Abstract Doc Link 12588347 Disease Relevance 0.14 Pain Relevance 0.14
The concentrations of FVII:C and FVII:Ag were not modified as compared with baseline values.
Positive_regulation (concentrations) of FVII
14) Confidence 0.03 Published 2003 Journal Br. J. Haematol. Section Abstract Doc Link 12588347 Disease Relevance 0.14 Pain Relevance 0.14
Our aim was to develop consensus guidelines for use of recombinant activated factor VII (rFVIIa) in massive hemorrhage.


Positive_regulation (activated) of factor VII associated with cva
15) Confidence 0.01 Published 2006 Journal Crit Care Section Abstract Doc Link PMC1750973 Disease Relevance 0.41 Pain Relevance 0.08
Recombinant activated factor VII (rFVIIa, NovoSeven®; Novo Nordisk, Copenhagen, Denmark) may be useful in the treatment of coagulopathic bleeding.
Positive_regulation (activated) of factor VII associated with hemorrhage
16) Confidence 0.01 Published 2006 Journal Crit Care Section Body Doc Link PMC1750973 Disease Relevance 1.40 Pain Relevance 0.04
Recommendations on the use of recombinant activated factor VII as an adjunctive treatment for massive bleeding ┬ľ a European perspective

Introduction

Positive_regulation (activated) of factor VII associated with hemorrhage
17) Confidence 0.01 Published 2006 Journal Crit Care Section Title Doc Link PMC1750973 Disease Relevance 0.77 Pain Relevance 0.08

General Comments

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