INT286993

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Context Info
Confidence 0.63
First Reported 2009
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 23
Total Number 23
Disease Relevance 14.38
Pain Relevance 0.89

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
Terminalia 1
gland 1
body 1
CA5P (Homo sapiens)
Pain Link Frequency Relevance Heat
cryotherapy 294 99.90 Very High Very High Very High
Potency 43 92.72 High High
Pain 24 76.76 Quite High
imagery 4 5.00 Very Low Very Low Very Low
Paracetamol 1 5.00 Very Low Very Low Very Low
Pain refractory 1 5.00 Very Low Very Low Very Low
Analgesic 1 5.00 Very Low Very Low Very Low
rheumatoid arthritis 1 5.00 Very Low Very Low Very Low
backache 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Prostate Cancer 1491 100.00 Very High Very High Very High
Recurrence 168 99.50 Very High Very High Very High
Heterotopic Ossification 21 99.12 Very High Very High Very High
Cancer 840 97.32 Very High Very High Very High
Disease 592 97.08 Very High Very High Very High
Aseptic Necrosis Of Bone 4 96.00 Very High Very High Very High
Toxicity 42 94.08 High High
Disease Progression 63 92.72 High High
Urolithiasis 1 87.60 High High
Aging 21 86.16 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In our opinion, the leakage of CaP cement should be prevented during vertebroplasty, and CaP should not be used in patients with vertebral osteonecrosis.
Localization (leakage) of CaP associated with aseptic necrosis of bone
1) Confidence 0.63 Published 2009 Journal Osteoporos Int Section Body Doc Link PMC2777211 Disease Relevance 0.79 Pain Relevance 0
Hence, it is concluded that saponins present in the purified n-butanol fraction from the bark of Terminalia arjuna are able to inhibit CaP mineralization and COM crystal growth in vitro.
Localization (mineralization) of CaP in Terminalia
2) Confidence 0.42 Published 2010 Journal Indian Journal of Pharmaceutical Sciences Section Body Doc Link PMC3003167 Disease Relevance 0.16 Pain Relevance 0
Moreover, in a study by Hubosky et al at 18-month follow-up, cryosurgery patients had better urinary function compared with a series of brachytherapy patients, and this improvement was still present at 24 months.58 Robinson et al presented quality of life (QoL) outcomes from a single institution randomized trial comparing EBRT with cryotherapy for localized CaP.
Localization (localized) of CaP associated with cryotherapy and prostate cancer
3) Confidence 0.34 Published 2010 Journal Clin Interv Aging Section Body Doc Link PMC2920199 Disease Relevance 0.60 Pain Relevance 0.17
The field of radiation oncology for the treatment of localized CaP is constantly being reevaluated to optimize delivery and optimize cancer control but also to minimize damage to surrounding normal tissues.
Localization (localized) of CaP associated with cancer and prostate cancer
4) Confidence 0.34 Published 2010 Journal Clin Interv Aging Section Body Doc Link PMC2920199 Disease Relevance 0.56 Pain Relevance 0
Stereotactic body radiotherapy is being rapidly deployed in the treatment of localized CaP.
Localization (localized) of CaP in body associated with prostate cancer
5) Confidence 0.34 Published 2010 Journal Clin Interv Aging Section Body Doc Link PMC2920199 Disease Relevance 0.61 Pain Relevance 0
Many elderly men with localized CaP receive only hormonal therapy.
Localization (localized) of CaP associated with prostate cancer
6) Confidence 0.34 Published 2010 Journal Clin Interv Aging Section Body Doc Link PMC2920199 Disease Relevance 0.81 Pain Relevance 0.08
However, the study has been criticized, as the EBRT patients received on average RT dose of 70 Gy, which is currently considered a low dose, as dose escalation above this level has shown to improve biochemical disease specific survival.26 Regardless, long term outcomes after RP are strong with RP considered by most to be the “gold standard” in the treatment of localized CaP.
Localization (localized) of CaP associated with prostate cancer and disease
7) Confidence 0.32 Published 2010 Journal Clin Interv Aging Section Body Doc Link PMC2920199 Disease Relevance 0.65 Pain Relevance 0
Jones et al recently published the largest series of patients undergoing whole gland cryotherapy as primary treatment, all of whom were included in the Cryo On-Line Database (COLD) registry the largest cohort published regarding whole gland cryotherapy for localized CaP.
Localization (localized) of CaP in gland associated with cryotherapy and prostate cancer
8) Confidence 0.32 Published 2010 Journal Clin Interv Aging Section Body Doc Link PMC2920199 Disease Relevance 0.45 Pain Relevance 0.16
As illustrated in this paper, there are numerous treatment options available for the management of localized CaP.
Localization (localized) of CaP associated with prostate cancer
9) Confidence 0.30 Published 2010 Journal Clin Interv Aging Section Body Doc Link PMC2920199 Disease Relevance 0.69 Pain Relevance 0
D’Amico and colleagues developed the concept of risk stratification, allowing the classification of men into low-, intermediate-, and high-risk pretreatment groups using a combination of clinical data: prostate-specific antigen (PSA), Gleason sum, and clinical stage (Table 1).2 The classification was originally developed to estimate the risk of biochemical recurrence following treatment for localized CaP and has become an important component in treatment recommendations.
Localization (localized) of CaP associated with prostate cancer and recurrence
10) Confidence 0.30 Published 2010 Journal Clin Interv Aging Section Body Doc Link PMC2920199 Disease Relevance 0.88 Pain Relevance 0
Applying the Phoenix definition to the data from men accumulated in that registry, 91 percent of men with low-risk, 78 percent of men with intermediate-risk, and 62 percent of men with high-risk, localized CaP experienced biochemical recurrence.63
Localization (localized) of CaP associated with prostate cancer and recurrence
11) Confidence 0.30 Published 2010 Journal Clin Interv Aging Section Body Doc Link PMC2920199 Disease Relevance 0.41 Pain Relevance 0.11
Currently, the treatment of localized CaP remains controversial.
Localization (localized) of CaP associated with prostate cancer
12) Confidence 0.30 Published 2010 Journal Clin Interv Aging Section Body Doc Link PMC2920199 Disease Relevance 0.62 Pain Relevance 0
Although, only recently, the AUA has accepted cryosurgery as a primary modality in treatment of localized CaP, published in Best Practice Statement on Cryosurgery for the Treatment of Localized Prostate Cancer.56 Cryotherapy is currently indicated in low-risk patients as an alternative to prostatectomy or radiotherapy, in higher-surgical-risk patients as primary therapy, and in patients who have not responded to radiation therapy as a salvage procedure.
Localization (localized) of CaP associated with cryotherapy and prostate cancer
13) Confidence 0.28 Published 2010 Journal Clin Interv Aging Section Body Doc Link PMC2920199 Disease Relevance 0.67 Pain Relevance 0.24
Outcome of RP is related much more to the preoperative comorbidity than to age alone.29 A life expectancy >10 years is the most frequently used benchmark for prostatectomy as definitive therapy for patients with localized CaP.30
Localization (localized) of CaP associated with prostate cancer
14) Confidence 0.28 Published 2010 Journal Clin Interv Aging Section Body Doc Link PMC2920199 Disease Relevance 0.50 Pain Relevance 0
Growing in popularity are “treatment” approaches for localized, asymptomatic CaP that do not involve an active intervention: active surveillance and watchful waiting (WW).
Localization (localized) of CaP associated with prostate cancer
15) Confidence 0.28 Published 2010 Journal Clin Interv Aging Section Body Doc Link PMC2920199 Disease Relevance 1.02 Pain Relevance 0
As noted by the AUA, various factors must be taken into consideration when making a collective decision in the man with clinically localized CaP.70 Consideration for enrolling the patient in a randomized trial is always a top priority as we move the care of our patients ahead.
Localization (localized) of CaP associated with prostate cancer
16) Confidence 0.26 Published 2010 Journal Clin Interv Aging Section Body Doc Link PMC2920199 Disease Relevance 0.65 Pain Relevance 0.04
Often, a patient with newly diagnosed localized CaP seeks the “right” answer from his treating physicians.
Localization (localized) of CaP associated with prostate cancer
17) Confidence 0.26 Published 2010 Journal Clin Interv Aging Section Body Doc Link PMC2920199 Disease Relevance 0.58 Pain Relevance 0
This article will discuss surgical and nonsurgical options available for the treatment of newly diagnosed localized CaP and will highlight some of the advances in each area.
Localization (localized) of CaP associated with prostate cancer
18) Confidence 0.26 Published 2010 Journal Clin Interv Aging Section Body Doc Link PMC2920199 Disease Relevance 0.92 Pain Relevance 0
Widespread screening with prostate-specific antigen (PSA) has led to a significant increase in the detection of early stage, clinically localized prostate cancer (CaP).
Localization (localized) of CaP associated with prostate cancer
19) Confidence 0.26 Published 2010 Journal Clin Interv Aging Section Abstract Doc Link PMC2920199 Disease Relevance 0.44 Pain Relevance 0
In fact, short of encouraging participation in clinical trials, it is difficult to define the “optimal” way to treat localized CaP.
Localization (localized) of CaP associated with prostate cancer
20) Confidence 0.26 Published 2010 Journal Clin Interv Aging Section Body Doc Link PMC2920199 Disease Relevance 0.62 Pain Relevance 0

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