INT287

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Context Info
Confidence 0.81
First Reported 1977
Last Reported 2010
Negated 6
Speculated 8
Reported most in Abstract
Documents 518
Total Number 526
Disease Relevance 86.84
Pain Relevance 364.04

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Cck) extracellular region (Cck)
Anatomy Link Frequency
spinal 17
spinal cord 16
plasma 16
dorsal horn 13
neurons 10
Cck (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Cholecystokinin 3604 100.00 Very High Very High Very High
antagonist 347 100.00 Very High Very High Very High
Opioid 257 100.00 Very High Very High Very High
Somatostatin 245 100.00 Very High Very High Very High
qutenza 200 100.00 Very High Very High Very High
gABA 191 100.00 Very High Very High Very High
Enkephalin 176 100.00 Very High Very High Very High
substance P 166 100.00 Very High Very High Very High
Neuropeptide 138 100.00 Very High Very High Very High
opiate 136 100.00 Very High Very High Very High
Disease Link Frequency Relevance Heat
Hypersensitivity 10 100.00 Very High Very High Very High
Obesity 32 99.98 Very High Very High Very High
Pain 150 99.92 Very High Very High Very High
Pancreatitis 522 99.84 Very High Very High Very High
Urological Neuroanatomy 94 99.84 Very High Very High Very High
Gallstones 24 99.84 Very High Very High Very High
Anaplastic Astrocytoma 3 99.84 Very High Very High Very High
Gallbladder Disease 9 99.80 Very High Very High Very High
Bardet-biedl Syndrome 24 99.68 Very High Very High Very High
Functional Bowel Disorder 14 99.68 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Vagally mediated, nonparacrine effects of cholecystokinin-8s on rat pancreatic exocrine secretion.
Localization (secretion) of cholecystokinin associated with qutenza and cholecystokinin
1) Confidence 0.81 Published 2007 Journal Am. J. Physiol. Gastrointest. Liver Physiol. Section Title Doc Link 17569741 Disease Relevance 0 Pain Relevance 0.59
Since the neuropeptide cholecystokinin (CCK) plays a role in the modulation of opiate-induced analgesia, the morphine-mediated release of CCK in the spinal cord of rats was compared with in vivo microdialysis in normals and different pain models.
Localization (release) of CCK in spinal cord associated with pain, neuropeptide, opiate, cholecystokinin, spinal cord, morphine and analgesia
2) Confidence 0.81 Published 1998 Journal Neurosci. Lett. Section Abstract Doc Link 9596344 Disease Relevance 0.44 Pain Relevance 1.65
In contrast, morphine did not induce CCK release during carrageenan-induced inflammation.
Neg (not) Localization (release) of CCK associated with inflammation, cholecystokinin and morphine
3) Confidence 0.81 Published 1998 Journal Neurosci. Lett. Section Abstract Doc Link 9596344 Disease Relevance 0.48 Pain Relevance 1.94
Differential release of cholecystokinin by morphine in rat spinal cord.
Localization (release) of cholecystokinin in spinal cord associated with narcan, cholecystokinin, spinal cord and morphine
4) Confidence 0.81 Published 1998 Journal Neurosci. Lett. Section Title Doc Link 9596344 Disease Relevance 0.49 Pain Relevance 2.03
These results suggest that protein in the duodenum decreases proximal gastric motor function via release of CCK and a vagal capsaicin-sensitive afferent pathway.
Localization (release) of CCK in proximal associated with qutenza and cholecystokinin
5) Confidence 0.81 Published 1991 Journal Peptides Section Abstract Doc Link 1815214 Disease Relevance 0 Pain Relevance 0.62
Indeed, during reintroduction of precollected pancreatic juice into the duodenum, when the release of CCK is known to be almost totally eliminated, pancreatic secretion was not significantly modified by the same doses.
Localization (release) of CCK in duodenum associated with cholecystokinin
6) Confidence 0.81 Published 1988 Journal Pancreas Section Abstract Doc Link 3174609 Disease Relevance 0 Pain Relevance 0.16
Activation of 5-HT3 receptors was found to increase CCK release from rat cortical or nucleus accumbens synaptosomes.
Localization (release) of CCK in nucleus accumbens associated with nucleus accumbens and cholecystokinin
7) Confidence 0.81 Published 1993 Journal Neurochem. Int. Section Abstract Doc Link 8513278 Disease Relevance 0.42 Pain Relevance 1.07
Similar increases in plasma CCK levels and pancreatic secretion were observed with duodenal administration of casein.
Localization (secretion) of CCK in plasma
8) Confidence 0.81 Published 1994 Journal Gastroenterology Section Body Doc Link 8039628 Disease Relevance 0 Pain Relevance 0
This potassium-stimulated release of CCK was Ca2+-dependent.
Localization (release) of CCK associated with cholecystokinin
9) Confidence 0.81 Published 1987 Journal Brain Res. Section Abstract Doc Link 2884011 Disease Relevance 0 Pain Relevance 0.86
Previous studies on the release of CCK from cp have focused on the influence of dopamine agonists.
Localization (release) of CCK associated with dopamine, agonist and cholecystokinin
10) Confidence 0.81 Published 1987 Journal Brain Res. Section Abstract Doc Link 2884011 Disease Relevance 0 Pain Relevance 0.70
The release of CCK from rat cp slices in vitro stimulated by potassium was quantitated with a specific CCK radioimmunoassay.
Localization (release) of CCK associated with cholecystokinin
11) Confidence 0.81 Published 1987 Journal Brain Res. Section Abstract Doc Link 2884011 Disease Relevance 0 Pain Relevance 0.82
The identity of the substance in CM which inhibits CCK release from cp is still under investigation, though it appears not to be CCK, dopamine, acetylcholine, somatostatin, leucine enkephalin or gamma-aminobutyric acid.
Localization (release) of CCK associated with dopamine, somatostatin, enkephalin and cholecystokinin
12) Confidence 0.81 Published 1987 Journal Brain Res. Section Abstract Doc Link 2884011 Disease Relevance 0 Pain Relevance 1.03
Release media from cerebral cortex or cp (called 'conditioned media' or CM) inhibits the release of CCK from fresh slices of cp but not from cerebral cortex.
Localization (release) of CCK in cerebral cortex associated with cholecystokinin and cerebral cortex
13) Confidence 0.81 Published 1987 Journal Brain Res. Section Abstract Doc Link 2884011 Disease Relevance 0 Pain Relevance 1.05
The regulation of cholecystokinin release from rat caudatoputamen in vitro.
Localization (release) of cholecystokinin associated with cholecystokinin
14) Confidence 0.81 Published 1987 Journal Brain Res. Section Title Doc Link 2884011 Disease Relevance 0 Pain Relevance 0.85
Several lines of evidence indicate that the release of CCK from cp is inhibited by some other substance (or substances) released by a Ca2+-dependent mechanism from cp along with CCK.
Localization (release) of CCK associated with cholecystokinin
15) Confidence 0.81 Published 1987 Journal Brain Res. Section Abstract Doc Link 2884011 Disease Relevance 0 Pain Relevance 1.02
The present study has examined the influence of other neuroactive substances on the release of CCK.
Localization (release) of CCK associated with cholecystokinin
16) Confidence 0.81 Published 1987 Journal Brain Res. Section Abstract Doc Link 2884011 Disease Relevance 0 Pain Relevance 0.81
Maximal stimulation of CCK release was observed at 55 mM potassium.
Localization (release) of CCK associated with cholecystokinin
17) Confidence 0.81 Published 1987 Journal Brain Res. Section Abstract Doc Link 2884011 Disease Relevance 0 Pain Relevance 0.95
Increased cholecystokinin release in the rat anterior cingulate cortex during carrageenan-induced arthritis.
Localization (release) of cholecystokinin in anterior associated with anterior cingulate cortex, cholecystokinin and arthritis
18) Confidence 0.81 Published 2004 Journal Brain Res. Section Title Doc Link 15353211 Disease Relevance 0.82 Pain Relevance 1.34
In this study, a model of subchronic inflammatory pain in rats, carrageenan-induced monoarthritis, was used to study the effect of pain on the release of CCK-like immunoreactivity (CCK-LI) in the ACC.
Localization (release) of CCK in ACC associated with pain, ipn, anterior cingulate cortex and cholecystokinin
19) Confidence 0.81 Published 2004 Journal Brain Res. Section Abstract Doc Link 15353211 Disease Relevance 0.95 Pain Relevance 1.48
In this study, a model of subchronic inflammatory pain in rats, carrageenan-induced monoarthritis, was used to study the effect of pain on the release of CCK-like immunoreactivity (CCK-LI) in the ACC.
Localization (release) of CCK in ACC associated with pain, ipn, anterior cingulate cortex and cholecystokinin
20) Confidence 0.81 Published 2004 Journal Brain Res. Section Abstract Doc Link 15353211 Disease Relevance 0.94 Pain Relevance 1.47

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