INT287003

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Context Info
Confidence 0.34
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 3
Disease Relevance 3.10
Pain Relevance 0.63

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endoplasmic reticulum (Hmox1) enzyme binding (Hmox1) signal transducer activity (Hmox1)
cytosol (Hmox1) signal transduction (Hmox1) cell death (Hmox1)
Anatomy Link Frequency
blood vessels 2
Hmox1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
fibrosis 88 100.00 Very High Very High Very High
Inflammation 57 98.44 Very High Very High Very High
cytokine 21 76.64 Quite High
chemokine 4 72.56 Quite High
Inflammatory response 4 21.84 Low Low
anesthesia 3 5.00 Very Low Very Low Very Low
ketamine 2 5.00 Very Low Very Low Very Low
alcohol 2 5.00 Very Low Very Low Very Low
medulla 2 5.00 Very Low Very Low Very Low
antagonist 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Fibrosis 108 100.00 Very High Very High Very High
Sepsis 19 99.12 Very High Very High Very High
INFLAMMATION 65 98.44 Very High Very High Very High
Ureteral Obstruction 90 94.64 High High
Internal Fibrosis 18 92.56 High High
Hypotension 12 90.48 High High
Apoptosis 11 83.60 Quite High
Albuminuria 8 74.36 Quite High
Adhesions 4 74.04 Quite High
Proteinuria 14 63.76 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Immunocytochemical staining localizes an increase in HO-1 protein within smooth muscle cells of both large (aorta) and small (arterioles) blood vessels, and the induction of HO and subsequent CO could reduce vascular tone during septic shock [12].
Negative_regulation (reduce) of Positive_regulation (induction) of HO in blood vessels associated with sepsis
1) Confidence 0.34 Published 2008 Journal Ir J Med Sci Section Body Doc Link PMC2777231 Disease Relevance 0.60 Pain Relevance 0
Reversion of fibrosis by upregulation of HO-1 was associated with a decrease in pro-inflammatory and pro-fibrotic molecule expression
Negative_regulation (Reversion) of Positive_regulation (upregulation) of HO-1 associated with fibrosis and inflammation
2) Confidence 0.17 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3001459 Disease Relevance 1.27 Pain Relevance 0.34
In our study HO-1 upregulation decreased collagen deposition and FSP-1 positive cells infiltrate, in accordance to another study which demonstrated that animals subjected to UUO and then exposed to low doses of CO had reduced ?
Negative_regulation (decreased) of Positive_regulation (upregulation) of HO-1 associated with ureteral obstruction
3) Confidence 0.15 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3001459 Disease Relevance 1.22 Pain Relevance 0.29

General Comments

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