INT28703

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Context Info
Confidence 0.38
First Reported 1989
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 29
Total Number 30
Disease Relevance 19.81
Pain Relevance 4.93

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (TFPI) extracellular region (TFPI) plasma membrane (TFPI)
Anatomy Link Frequency
EPI 7
macrophage 2
platelet 2
heart 2
blood 1
TFPI (Homo sapiens)
Pain Link Frequency Relevance Heat
Potency 16 100.00 Very High Very High Very High
Clonidine 3 99.84 Very High Very High Very High
tolerance 40 99.68 Very High Very High Very High
analgesia 4 99.54 Very High Very High Very High
Inflammation 192 99.30 Very High Very High Very High
Catecholamine 54 98.66 Very High Very High Very High
Inflammatory response 31 97.88 Very High Very High Very High
Angina 57 96.08 Very High Very High Very High
cINOD 3 95.24 Very High Very High Very High
Migraine 1 90.72 High High
Disease Link Frequency Relevance Heat
Coccidioides Infection 17 100.00 Very High Very High Very High
Coagulation Disorder 42 99.98 Very High Very High Very High
Reprotox - General 1 8 99.76 Very High Very High Very High
Impaired Glucose Tolerance 40 99.68 Very High Very High Very High
Myocardial Infarction 128 99.48 Very High Very High Very High
INFLAMMATION 241 99.30 Very High Very High Very High
Disease 51 98.76 Very High Very High Very High
Hypercholesterolemia 4 98.68 Very High Very High Very High
Sepsis 123 98.56 Very High Very High Very High
Thrombosis 118 98.32 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
BACKGROUND: Changes in maternal catecholamines that accompany the onset of labor analgesia include a decrease in epinephrine (EPI) but no change in norepinephrine (NE).
Negative_regulation (decrease) of EPI in EPI associated with catecholamine and analgesia
1) Confidence 0.38 Published 2008 Journal Anesth. Analg. Section Abstract Doc Link 18292436 Disease Relevance 0 Pain Relevance 0.19
This observation may have implications for changes in uterine blood flow that may accompany the onset of labor analgesia in human parturients, as effective analgesia is accompanied by an acute decrease in circulating EPI levels.


Negative_regulation (decrease) of EPI in blood
2) Confidence 0.38 Published 2008 Journal Anesth. Analg. Section Body Doc Link 18292436 Disease Relevance 0 Pain Relevance 0
In washout experiments, removal of EPI with continued presence of NE resulted in vasoconstriction that was reversed by terbutaline.
Negative_regulation (removal) of EPI in EPI
3) Confidence 0.38 Published 2008 Journal Anesth. Analg. Section Body Doc Link 18292436 Disease Relevance 0 Pain Relevance 0
Plasma EPI increases after yohimbine and decreases after clonidine did not differ between groups.
Negative_regulation (decreases) of EPI in EPI
4) Confidence 0.36 Published 2000 Journal J. Gerontol. A Biol. Sci. Med. Sci. Section Body Doc Link 10795728 Disease Relevance 0 Pain Relevance 0
Furthermore, the production of tissue factor or inhibition of tissue-factor-pathway-inhibitor (TFPI) activates the extrinsic coagulation pathway [2,14], while the simultaneous decreased production of prostacyclin induces vasoconstriction and platelet aggregation.
Negative_regulation (inhibition) of TFPI in platelet associated with increased venous pressure under development
5) Confidence 0.32 Published 2010 Journal J Cardiothorac Surg Section Body Doc Link PMC2987921 Disease Relevance 0.74 Pain Relevance 0
Furthermore, the production of tissue factor or inhibition of tissue-factor-pathway-inhibitor (TFPI) activates the extrinsic coagulation pathway [2,14], while the simultaneous decreased production of prostacyclin induces vasoconstriction and platelet aggregation.
Negative_regulation (inhibition) of tissue-factor-pathway-inhibitor in platelet associated with increased venous pressure under development
6) Confidence 0.32 Published 2010 Journal J Cardiothorac Surg Section Body Doc Link PMC2987921 Disease Relevance 0.73 Pain Relevance 0
Several studies have reported high levels of total tissue factor pathway inhibitor (TFPI) antigen in patients with serum elevated cholesterol.
Negative_regulation (inhibitor) of TFPI associated with hypercholesterolemia
7) Confidence 0.25 Published 2003 Journal Thromb J Section Body Doc Link PMC179880 Disease Relevance 1.54 Pain Relevance 0.37
Several studies have reported high levels of total tissue factor pathway inhibitor (TFPI) antigen in patients with serum elevated cholesterol.
Negative_regulation (inhibitor) of tissue factor pathway associated with hypercholesterolemia
8) Confidence 0.25 Published 2003 Journal Thromb J Section Body Doc Link PMC179880 Disease Relevance 1.55 Pain Relevance 0.37
Tissue factor pathway inhibitor TFPI activity and thrombomodulin levels were increased in all elderly subjects, with positive association between HbA (1c), TFPI activity and vWF antigen.
Negative_regulation (inhibitor) of TFPI
9) Confidence 0.25 Published 2007 Journal Vascular Health and Risk Management Section Body Doc Link PMC2350146 Disease Relevance 1.18 Pain Relevance 0.21
Tissue factor pathway inhibitor TFPI activity and thrombomodulin levels were increased in all elderly subjects, with positive association between HbA (1c), TFPI activity and vWF antigen.
Negative_regulation (inhibitor) of Tissue factor pathway
10) Confidence 0.25 Published 2007 Journal Vascular Health and Risk Management Section Body Doc Link PMC2350146 Disease Relevance 1.24 Pain Relevance 0.21
To inhibit endogenous TFPI TF activity was measured using an FXa generation assay in the absence and presence of 100 ?
Negative_regulation (inhibit) of TFPI
11) Confidence 0.20 Published 2009 Journal Thromb J Section Body Doc Link PMC2714503 Disease Relevance 0.57 Pain Relevance 0.22
Maximal levels of tissue factor pathway inhibitor (TFPI) were observed at the beginning of CPB.
Negative_regulation (inhibitor) of TFPI
12) Confidence 0.19 Published 2007 Journal Crit Care Section Body Doc Link PMC2206501 Disease Relevance 0.42 Pain Relevance 0.12
The pellet fraction exhibited a clear TF activity, which further increased after inhibition of endogenous TFPI.
Negative_regulation (inhibition) of TFPI
13) Confidence 0.18 Published 2009 Journal Thromb J Section Body Doc Link PMC2714503 Disease Relevance 0.17 Pain Relevance 0
= macrophage inflammatory protein-1 alpha; NE/E = norepinephrine/epinephrine; PIC = paediatric intensive care; PVT = pulseless ventricular tachycardia; ROSC = return to spontaneous circulation; RSV = respiratory syncytial virus; RT-PCR = real-time polymerase chain reaction; TCPC = total cavo-pulmonary connection; TFPI = tissue factor pathway inhibitor; TP = terlipressin; TxB2 = thromboxane B2; VF = ventricular fibrillation.


Negative_regulation (inhibitor) of pathway in macrophage associated with heart rate under development, inflammation, arrhythmias 2 under development and respiratory syncytial virus
14) Confidence 0.17 Published 2007 Journal Crit Care Section Body Doc Link PMC2206501 Disease Relevance 1.15 Pain Relevance 0.05
= macrophage inflammatory protein-1 alpha; NE/E = norepinephrine/epinephrine; PIC = paediatric intensive care; PVT = pulseless ventricular tachycardia; ROSC = return to spontaneous circulation; RSV = respiratory syncytial virus; RT-PCR = real-time polymerase chain reaction; TCPC = total cavo-pulmonary connection; TFPI = tissue factor pathway inhibitor; TP = terlipressin; TxB2 = thromboxane B2; VF = ventricular fibrillation.


Negative_regulation (inhibitor) of TFPI in macrophage associated with heart rate under development, inflammation, arrhythmias 2 under development and respiratory syncytial virus
15) Confidence 0.17 Published 2007 Journal Crit Care Section Body Doc Link PMC2206501 Disease Relevance 1.16 Pain Relevance 0.05
Inclusion of propranolol (30 nM) inhibited EPI-induced ?
Negative_regulation (inhibited) of EPI-induced in EPI
16) Confidence 0.16 Published 2007 Journal BMC Pharmacol Section Body Doc Link PMC2234403 Disease Relevance 0 Pain Relevance 0.15
Maximal levels of tissue factor pathway inhibitor (TFPI) were observed at the beginning of CPB.
Negative_regulation (inhibitor) of pathway
17) Confidence 0.16 Published 2007 Journal Crit Care Section Body Doc Link PMC2206501 Disease Relevance 0.43 Pain Relevance 0.12
2A-AR signal causing loss of UK14,304 potency (-Log EC50 (M): Vehicle 6.9 ± 0.2; EPI 6.3 ± 0.2) and efficacy (Imax (%): Vehicle 68.2 ± 5.4; EPI 49.3 ± 10.4; p < 0.05; Fig. 3B).
Negative_regulation (loss) of EPI in EPI associated with potency
18) Confidence 0.16 Published 2007 Journal BMC Pharmacol Section Body Doc Link PMC2234403 Disease Relevance 0 Pain Relevance 0.13
2-AR as indicated by the inhibition of EPI-induced ?
Negative_regulation (inhibition) of EPI-induced in EPI
19) Confidence 0.16 Published 2007 Journal BMC Pharmacol Section Body Doc Link PMC2234403 Disease Relevance 0 Pain Relevance 0
2-AR responsiveness in cells and tissues after chronic epinephrine (EPI) or norepinephrine (NE) exposure may vary, depending on the ?
Negative_regulation (epinephrine) of EPI in EPI
20) Confidence 0.16 Published 2007 Journal BMC Pharmacol Section Abstract Doc Link PMC2234403 Disease Relevance 0.16 Pain Relevance 0

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