INT287031

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Context Info
Confidence 0.46
First Reported 2009
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 0.16
Pain Relevance 0.03

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Golgi apparatus (Prnp) endoplasmic reticulum (Prnp) nucleolus (Prnp)
plasma membrane (Prnp) nucleus (Prnp) cytoplasm (Prnp)
Anatomy Link Frequency
brains 2
Prnp (Mus musculus)
Pain Link Frequency Relevance Heat
Potency 2 58.88 Quite High
Thalamus 8 5.00 Very Low Very Low Very Low
Hippocampus 8 5.00 Very Low Very Low Very Low
anesthesia 4 5.00 Very Low Very Low Very Low
Central nervous system 2 5.00 Very Low Very Low Very Low
depression 2 5.00 Very Low Very Low Very Low
medulla 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Disease 28 83.40 Quite High
Creutzfeldt Jakob Disease 30 80.76 Quite High
Neuroblastoma 4 49.52 Quite Low
Sprains And Strains 22 32.00 Quite Low
Targeted Disruption 2 18.40 Low Low
Gliosis 10 5.00 Very Low Very Low Very Low
Scrapie 4 5.00 Very Low Very Low Very Low
Toxicity 4 5.00 Very Low Very Low Very Low
Neurodegenerative Disease 4 5.00 Very Low Very Low Very Low
Neurologic Manifestations 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The quinacrine concentrations needed for half-maximal depletion of PrPSc (EC50) in cell culture were reported to be ?
Positive_regulation (reported) of Negative_regulation (depletion) of PrPSc
1) Confidence 0.46 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2777304 Disease Relevance 0.08 Pain Relevance 0.03
In the brains of prion-inoculated MDR0/0 mice, PrPSc levels diminished upon the initiation of quinacrine treatment, remained low for several days, but gradually increased despite the continuous presence of the drug.
Positive_regulation (increased) of Negative_regulation (diminished) of PrPSc in brains
2) Confidence 0.38 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2777304 Disease Relevance 0.08 Pain Relevance 0

General Comments

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