INT287035

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Context Info
Confidence 0.02
First Reported 2009
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.48
Pain Relevance 0.12

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Gopc, Prtn3) cytosol (Prtn3) peptidase activity (Prtn3)
transport (Gopc) Golgi apparatus (Gopc) enzyme binding (Prtn3)
Anatomy Link Frequency
brain 1
Gopc (Mus musculus)
Prtn3 (Mus musculus)
Pain Link Frequency Relevance Heat
Hippocampus 4 64.60 Quite High
Thalamus 4 63.96 Quite High
medulla 1 41.28 Quite Low
anesthesia 2 5.00 Very Low Very Low Very Low
Central nervous system 1 5.00 Very Low Very Low Very Low
depression 1 5.00 Very Low Very Low Very Low
Potency 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Disease 14 83.56 Quite High
Gliosis 5 72.28 Quite High
Neurologic Manifestations 2 14.48 Low Low
Creutzfeldt Jakob Disease 15 5.00 Very Low Very Low Very Low
Sprains And Strains 11 5.00 Very Low Very Low Very Low
Neuroblastoma 2 5.00 Very Low Very Low Very Low
Scrapie 2 5.00 Very Low Very Low Very Low
Toxicity 2 5.00 Very Low Very Low Very Low
Neurodegenerative Disease 2 5.00 Very Low Very Low Very Low
Infection 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Two or three animals were sacrificed at 60, 75, 90 and 111 dpi, and the accumulation of protease-resistant PrPSc in the brain was analyzed by Western immunoblotting (Fig. 3A) and quantitative ELISA (Fig. 3B) following proteinase K (PK) digestion.
Fig Positive_regulation (following) of proteinase K in brain
1) Confidence 0.02 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2777304 Disease Relevance 0.48 Pain Relevance 0.12

General Comments

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