INT287041

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Context Info
Confidence 0.37
First Reported 2009
Last Reported 2010
Negated 2
Speculated 0
Reported most in Body
Documents 6
Total Number 7
Disease Relevance 3.40
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

intracellular (Vav1)
Vav1 (Mus musculus)
Pain Link Frequency Relevance Heat
anesthesia 7 5.00 Very Low Very Low Very Low
cytokine 2 5.00 Very Low Very Low Very Low
Inflammation 2 5.00 Very Low Very Low Very Low
Pain 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Lymphatic System Cancer 124 99.76 Very High Very High Very High
Glaucoma 108 99.60 Very High Very High Very High
Cancer 138 97.44 Very High Very High Very High
Leukemia 42 96.40 Very High Very High Very High
Targeted Disruption 11 94.16 High High
Ocular Hypertension 114 70.96 Quite High
Epstein-barr Virus 45 65.60 Quite High
Precursor Cell Lymphoblastic Leukemia-lymphoma 12 54.88 Quite High
Disease 18 50.00 Quite Low
Chronic Myeloid Leukemia 2 36.96 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The take home message of these studies is that the human VAV1 and RASGRF2 genes do not show a consistent and generalizable change pattern in hematopoietic tumors such as lymphomas, leukemias or myelomas.
VAV1 Neg (not) Binding (show) of associated with leukemia, lymphatic system cancer and cancer
1) Confidence 0.37 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2788417 Disease Relevance 1.02 Pain Relevance 0
The Vav1 and Rasgrf2 gene deficiencies seem to contribute differently to these two lymphoma stages.
Vav1 Binding (contribute) of associated with lymphatic system cancer
2) Confidence 0.37 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2788417 Disease Relevance 0.85 Pain Relevance 0
The most significant SNPs were chosen in this report to evaluate the association of VAV2, VAV3, and VAV1 in the cases.


VAV1 Binding (association) of
3) Confidence 0.33 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2816215 Disease Relevance 0.18 Pain Relevance 0
On the contrary, VAV1 showed no association with the POAG.
VAV1 Neg (no) Binding (association) of associated with glaucoma
4) Confidence 0.32 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2816215 Disease Relevance 0.99 Pain Relevance 0
Notably, M2 has been shown to target phosphorylation of the guanosine nucleotide exchange factors Vav1 and Vav2, and more recently has been shown form a trimolecular complex with Vav1 and the Src family tyrosine kinase Fyn [24] - although the functional consequences of these interactions remain unclear.
Vav1 Binding (complex) of
5) Confidence 0.24 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2777334 Disease Relevance 0.05 Pain Relevance 0
Additionally, the M2 protein harbors 2 tyrosine residues that are predicted to be potential phosphorylation sites and have been shown to be essential for the formation of a trimolecular complex with Vav1 and the Src family kinase Fyn [31].
Vav1 Binding (complex) of
6) Confidence 0.24 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2777334 Disease Relevance 0.16 Pain Relevance 0
Additionally, the M2 protein harbors 2 tyrosine residues that are predicted to be potential phosphorylation sites and have been shown to be essential for the formation of a trimolecular complex with Vav1 and the Src family kinase Fyn [31].
Vav1 Binding (formation) of
7) Confidence 0.24 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2777334 Disease Relevance 0.16 Pain Relevance 0

General Comments

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