INT287041

Context Info Confidence 0.37 First Reported 2009 Last Reported 2010 Negated 2 Speculated 0 Reported most in Body Documents 6 Total Number 7 Disease Relevance 3.40 Pain Relevance 0

intracellular (Vav1)

Vav1 (Mus musculus)

Pain Link Frequency Relevance Heat anesthesia 7 5.00 cytokine 2 5.00 Inflammation 2 5.00 Pain 2 5.00

Disease Link Frequency Relevance Heat Lymphatic System Cancer 124 99.76 Glaucoma 108 99.60 Cancer 138 97.44 Leukemia 42 96.40 Targeted Disruption 11 94.16 Ocular Hypertension 114 70.96 Epstein-barr Virus 45 65.60 Precursor Cell Lymphoblastic Leukemia-lymphoma 12 54.88 Disease 18 50.00 Chronic Myeloid Leukemia 2 36.96

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

The take home message of these studies is that the human VAV1 and RASGRF2 genes do not show a consistent and generalizable change pattern in hematopoietic tumors such as lymphomas, leukemias or myelomas.

VAV1 Neg (not) Binding (show) of associated with leukemia, lymphatic system cancer and cancer

1) Confidence 0.37 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2788417 Disease Relevance 1.02 Pain Relevance 0

The Vav1 and Rasgrf2 gene deficiencies seem to contribute differently to these two lymphoma stages.

Vav1 Binding (contribute) of associated with lymphatic system cancer

2) Confidence 0.37 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2788417 Disease Relevance 0.85 Pain Relevance 0

The most significant SNPs were chosen in this report to evaluate the association of VAV2, VAV3, and VAV1 in the cases.

VAV1 Binding (association) of

3) Confidence 0.33 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2816215 Disease Relevance 0.18 Pain Relevance 0

On the contrary, VAV1 showed no association with the POAG.

VAV1 Neg (no) Binding (association) of associated with glaucoma

4) Confidence 0.32 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2816215 Disease Relevance 0.99 Pain Relevance 0

Notably, M2 has been shown to target phosphorylation of the guanosine nucleotide exchange factors Vav1 and Vav2, and more recently has been shown form a trimolecular complex with Vav1 and the Src family tyrosine kinase Fyn [24] - although the functional consequences of these interactions remain unclear.

Vav1 Binding (complex) of

5) Confidence 0.24 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2777334 Disease Relevance 0.05 Pain Relevance 0

Additionally, the M2 protein harbors 2 tyrosine residues that are predicted to be potential phosphorylation sites and have been shown to be essential for the formation of a trimolecular complex with Vav1 and the Src family kinase Fyn [31].

Vav1 Binding (complex) of

6) Confidence 0.24 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2777334 Disease Relevance 0.16 Pain Relevance 0

Additionally, the M2 protein harbors 2 tyrosine residues that are predicted to be potential phosphorylation sites and have been shown to be essential for the formation of a trimolecular complex with Vav1 and the Src family kinase Fyn [31].

Vav1 Binding (formation) of

7) Confidence 0.24 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2777334 Disease Relevance 0.16 Pain Relevance 0

General Comments

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