INT287052

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Context Info
Confidence 0.50
First Reported 2009
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 4
Disease Relevance 3.51
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

intracellular (Vav1)
Anatomy Link Frequency
plasma cell 1
B-cell 1
Vav1 (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 3 5.00 Very Low Very Low Very Low
Pain 3 5.00 Very Low Very Low Very Low
anesthesia 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Chronic Lymphoid Leukemia 12 99.84 Very High Very High Very High
Cancer 197 99.64 Very High Very High Very High
Lymphatic System Cancer 144 97.80 Very High Very High Very High
Multiple Myeloma 3 97.28 Very High Very High Very High
Leukemia 63 96.96 Very High Very High Very High
Targeted Disruption 4 93.28 High High
Lymphadenopathy 6 92.44 High High
Precursor Cell Lymphoblastic Leukemia-lymphoma 18 89.60 High High
Htlv Types I And Ii 3 81.20 Quite High
Chronic Myeloid Leukemia 3 77.68 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These thymic alterations were detected at very high rates in animals of both Vav1–/– (?
Positive_regulation (rates) of Vav1
1) Confidence 0.50 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2788417 Disease Relevance 1.09 Pain Relevance 0
Thus, it seems likely that under some conditions M2 activation of Vav may lead to Blimp-1 expression and entry into the plasma cell program (Fig. 6E).
Positive_regulation (activation) of Vav in plasma cell
2) Confidence 0.46 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2777334 Disease Relevance 0.15 Pain Relevance 0
These analyses indicated that VAV1 mRNA was overexpressed in chronic lymphocytic leukemia, diffuse large B–cell lymphoma and smoldering myeloma relative to control cells (Table 1).
Positive_regulation (overexpressed) of VAV1 in B-cell associated with chronic lymphoid leukemia, lymphatic system cancer and multiple myeloma
3) Confidence 0.46 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2788417 Disease Relevance 1.14 Pain Relevance 0
Instead, we could not detect any patient tumor subgroup showing upregulation of VAV1 relative to the total patient cohort.
Positive_regulation (upregulation) of VAV1 associated with cancer
4) Confidence 0.46 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2788417 Disease Relevance 1.13 Pain Relevance 0

General Comments

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