INT287058

Context Info Confidence 0.03 First Reported 2009 Last Reported 2009 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 0.09 Pain Relevance 0

signal transduction (Chrm2) plasma membrane (Chrm2) signal transducer activity (Chrm2)

Anatomy Link Frequency B cell 2 Chrm2 (Mus musculus) Igis1 (Mus musculus)

Pain Link Frequency Relevance Heat anesthesia 1 5.00

Disease Link Frequency Relevance Heat Lymphatic System Cancer 12 93.04 Infection 29 21.76 Epstein-barr Virus 15 7.52 Sarcoma 2 5.00 Cancer 2 5.00 Viral Infection 2 5.00 Sleep Disorders 1 5.00 Targeted Disruption 1 5.00 Lymphoproliferative Disease 1 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Taken together, these data implicate a role for M2 in facilitating B cell differentiation through the germinal center reaction and perhaps directly impacting immunoglobulin isotype switching.

M2 Regulation (role) of Positive_regulation (impacting) of immunoglobulin isotype in B cell

1) Confidence 0.03 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2777334 Disease Relevance 0.09 Pain Relevance 0

General Comments

This test has worked.