INT287090

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Context Info
Confidence 0.18
First Reported 2009
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 4
Disease Relevance 2.77
Pain Relevance 0.86

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (T) DNA binding (T) cytoplasm (T)
Anatomy Link Frequency
dorsal horn 2
T (Mus musculus)
Pain Link Frequency Relevance Heat
spinal dorsal horn 20 99.68 Very High Very High Very High
Inflammation 44 96.24 Very High Very High Very High
Root ganglion neuron 8 73.60 Quite High
Neuropathic pain 16 68.96 Quite High
Pain 36 66.16 Quite High
qutenza 40 65.44 Quite High
Hyperalgesia 8 46.28 Quite Low
Lasting pain 8 45.68 Quite Low
medulla 4 44.96 Quite Low
Thermal hyperalgesia 4 42.68 Quite Low
Disease Link Frequency Relevance Heat
Targeted Disruption 24 99.80 Very High Very High Very High
Down Syndrome 4 99.20 Very High Very High Very High
Death 4 97.84 Very High Very High Very High
INFLAMMATION 48 96.24 Very High Very High Very High
Disease 4 94.92 High High
Nociception 52 85.52 High High
Sprains And Strains 4 75.92 Quite High
Ganglion Cysts 8 73.20 Quite High
Acquired Immune Deficiency Syndrome Or Hiv Infection 12 70.16 Quite High
Neuropathic Pain 28 68.96 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Generation of trkB.T1 wildtype and knockout mice
Regulation (Generation) of Gene_expression (wildtype) of T1 associated with targeted disruption
1) Confidence 0.18 Published 2009 Journal Mol Pain Section Body Doc Link PMC2777863 Disease Relevance 0.43 Pain Relevance 0.07
Moreover, altered trkB.T1 expression can affect synaptic plasticity.
Regulation (affect) of Gene_expression (expression) of T1
2) Confidence 0.18 Published 2009 Journal Mol Pain Section Body Doc Link PMC2777863 Disease Relevance 0.73 Pain Relevance 0.19
Here, we demonstrate that trkB.T1 mRNA and protein are both significantly up-regulated in the spinal dorsal horn following systemic antiretroviral drug administration and hind paw inflammation (Figure 1).
Regulation (regulated) of Gene_expression (mRNA) of T1 in dorsal horn associated with inflammation and spinal dorsal horn
3) Confidence 0.18 Published 2009 Journal Mol Pain Section Body Doc Link PMC2777863 Disease Relevance 0.88 Pain Relevance 0.42
Moreover, altered trkB.T1 expression can affect synaptic plasticity.
Regulation (altered) of Gene_expression (expression) of T1
4) Confidence 0.18 Published 2009 Journal Mol Pain Section Body Doc Link PMC2777863 Disease Relevance 0.73 Pain Relevance 0.19

General Comments

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