INT287093

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Context Info
Confidence 0.28
First Reported 2009
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 1.47
Pain Relevance 0.86

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (T) DNA binding (T) cytoplasm (T)
T (Mus musculus)
Pain Link Frequency Relevance Heat
intrathecal 4 90.16 High High
induced neuropathy 2 89.64 High High
Lasting pain 4 83.60 Quite High
Pain 18 64.28 Quite High
Dorsal horn 8 56.00 Quite High
qutenza 20 7.92 Low Low
Inflammation 22 6.68 Low Low
spinal dorsal horn 10 5.00 Very Low Very Low Very Low
withdrawal 10 5.00 Very Low Very Low Very Low
Neuropathic pain 8 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Hypersensitivity 28 97.68 Very High Very High Very High
Neuropathic Pain 14 89.64 High High
Pain 22 82.72 Quite High
Nociception 26 60.32 Quite High
INFLAMMATION 24 6.68 Low Low
Targeted Disruption 12 5.00 Very Low Very Low Very Low
Hyperalgesia 6 5.00 Very Low Very Low Very Low
Acquired Immune Deficiency Syndrome Or Hiv Infection 6 5.00 Very Low Very Low Very Low
Ganglion Cysts 4 5.00 Very Low Very Low Very Low
Nervous System Injury 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Thus, our results demonstrating attenuation in thermal and mechanical sensitivity in the absence of trkB.T1 could be because increased trkB.T1 expression induces increased intracellular calcium signaling which promotes hypersensitivity.
Positive_regulation (increased) of Gene_expression (expression) of T1 associated with hypersensitivity
1) Confidence 0.28 Published 2009 Journal Mol Pain Section Body Doc Link PMC2777863 Disease Relevance 0.74 Pain Relevance 0.43
Thus, our results demonstrating attenuation in thermal and mechanical sensitivity in the absence of trkB.T1 could be because increased trkB.T1 expression induces increased intracellular calcium signaling which promotes hypersensitivity.
Positive_regulation (induces) of Gene_expression (expression) of T1 associated with hypersensitivity
2) Confidence 0.19 Published 2009 Journal Mol Pain Section Body Doc Link PMC2777863 Disease Relevance 0.74 Pain Relevance 0.43

General Comments

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