INT287096

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Context Info
Confidence 0.16
First Reported 2009
Last Reported 2009
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 2
Disease Relevance 1.15
Pain Relevance 0.60

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (Bdnf) cytoplasmic membrane-bounded vesicle (Bdnf)
Bdnf (Mus musculus)
FL (Mus musculus)
Pain Link Frequency Relevance Heat
Lasting pain 4 99.96 Very High Very High Very High
Pain 18 97.84 Very High Very High Very High
Central nervous system 2 97.56 Very High Very High Very High
spinal dorsal horn 10 87.84 High High
medulla 2 85.52 High High
Hyperalgesia 4 83.12 Quite High
Neuropathic pain 8 65.92 Quite High
Inflammation 22 47.44 Quite Low
qutenza 20 5.00 Very Low Very Low Very Low
withdrawal 10 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Nociception 26 100.00 Very High Very High Very High
Pain 22 99.96 Very High Very High Very High
Hyperalgesia 6 83.12 Quite High
Acquired Immune Deficiency Syndrome Or Hiv Infection 6 67.12 Quite High
Targeted Disruption 12 66.24 Quite High
Neuropathic Pain 14 65.92 Quite High
Nervous System Injury 4 60.56 Quite High
Hypersensitivity 28 57.04 Quite High
INFLAMMATION 24 47.44 Quite Low
Ganglion Cysts 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
BDNF exerts effects on nociception by binding to trkB.FL and initiating intracellular signaling cascades that lead to transcriptional changes.
BDNF Binding (binding) of FL associated with nociception
1) Confidence 0.16 Published 2009 Journal Mol Pain Section Body Doc Link PMC2777863 Disease Relevance 0.56 Pain Relevance 0.36
In animal models of chronic pain, BDNF exerts its effects on nociceptive processing by binding to the full-length receptor tropomyosin-related kinase B (trkB.FL) and transducing intracellular signaling to produce nocifensive behaviors.
BDNF Binding (binding) of FL associated with nociception and lasting pain
2) Confidence 0.12 Published 2009 Journal Mol Pain Section Abstract Doc Link PMC2777863 Disease Relevance 0.59 Pain Relevance 0.24

General Comments

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