INT287099

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Context Info
Confidence 0.10
First Reported 2009
Last Reported 2009
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 2
Disease Relevance 1.10
Pain Relevance 0.69

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (Bdnf) nucleus (T) cytoplasmic membrane-bounded vesicle (Bdnf)
DNA binding (T) cytoplasm (T)
Anatomy Link Frequency
tail 1
Bdnf (Mus musculus)
T (Mus musculus)
Pain Link Frequency Relevance Heat
Pain 18 90.24 High High
Lasting pain 4 86.76 High High
Central nervous system 2 84.40 Quite High
Neuropathic pain 8 83.20 Quite High
Dorsal horn 8 81.96 Quite High
induced neuropathy 2 72.08 Quite High
spinal dorsal horn 10 71.20 Quite High
intrathecal 4 70.48 Quite High
Inflammation 22 64.72 Quite High
qutenza 20 33.88 Quite Low
Disease Link Frequency Relevance Heat
Pain 22 90.24 High High
Nociception 26 88.36 High High
Acquired Immune Deficiency Syndrome Or Hiv Infection 6 84.40 Quite High
Neuropathic Pain 14 83.20 Quite High
INFLAMMATION 24 64.72 Quite High
Hypersensitivity 28 61.76 Quite High
Sprains And Strains 2 28.52 Quite Low
Targeted Disruption 12 5.00 Very Low Very Low Very Low
Hyperalgesia 6 5.00 Very Low Very Low Very Low
Ganglion Cysts 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The available evidence regarding trkB.T1 signaling suggests that BDNF binding to trkB.T1 causes increased intracellular calcium release [28].
BDNF Binding (binding) of T1
1) Confidence 0.10 Published 2009 Journal Mol Pain Section Body Doc Link PMC2777863 Disease Relevance 0.45 Pain Relevance 0.41
TrkB.T1 binds BDNF with high affinity; however the unique 11 amino acid intracellular cytoplasmic tail lacks the kinase domain of trkB.FL.
BDNF Binding (binds) of T1 in tail
2) Confidence 0.09 Published 2009 Journal Mol Pain Section Abstract Doc Link PMC2777863 Disease Relevance 0.65 Pain Relevance 0.28

General Comments

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