INT2871

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Context Info
Confidence 0.50
First Reported 1977
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 9
Total Number 9
Disease Relevance 2.80
Pain Relevance 4.78

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Comt) plasma membrane (Comt) cytoplasm (Comt)
Anatomy Link Frequency
brain 2
phagocyte 2
neurons 1
striatum 1
Comt (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Catechol-O-methyltransferase 236 100.00 Very High Very High Very High
Catecholamine 102 100.00 Very High Very High Very High
narcan 4 99.84 Very High Very High Very High
monoamine 6 99.76 Very High Very High Very High
opiate 1 99.32 Very High Very High Very High
Inflammation 38 98.72 Very High Very High Very High
withdrawal 5 98.08 Very High Very High Very High
Dopamine 74 96.96 Very High Very High Very High
Enkephalin 15 95.60 Very High Very High Very High
Endogenous opioid 1 94.16 High High
Disease Link Frequency Relevance Heat
Injury 20 98.86 Very High Very High Very High
INFLAMMATION 66 98.72 Very High Very High Very High
Depression 38 90.04 High High
Attention Deficit Hyperactivity Disorder 1 85.48 High High
Disease 138 84.72 Quite High
Homocystinuria 1 72.28 Quite High
Affective Disorder 4 72.24 Quite High
Hyperhomocysteinemia 4 70.08 Quite High
Depressive Disorder 1 66.00 Quite High
Myocardial Infarction 5 64.88 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This therapeutic
               principle supports LD metabolism via the enzyme catechol-O-methyltransferase (COMT)
               and delivers more LD to the brain.


Positive_regulation (enzyme) of catechol-O-methyltransferase in brain associated with catechol-o-methyltransferase
1) Confidence 0.50 Published 2009 Journal Patient Prefer Adherence Section Body Doc Link PMC2778405 Disease Relevance 0.17 Pain Relevance 0.28
This therapeutic
               principle supports LD metabolism via the enzyme catechol-O-methyltransferase (COMT)
               and delivers more LD to the brain.


Positive_regulation (enzyme) of COMT in brain associated with catechol-o-methyltransferase
2) Confidence 0.50 Published 2009 Journal Patient Prefer Adherence Section Body Doc Link PMC2778405 Disease Relevance 0.17 Pain Relevance 0.28
Additional studies will be required to provide more information about the COMT gene in cardiovascular health.



Positive_regulation (information) of COMT associated with catechol-o-methyltransferase
3) Confidence 0.50 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1779620 Disease Relevance 0.27 Pain Relevance 0.12
However there is an essential
               pharmacological discrepancy between both compounds, since tolcapone but not EN also
               occurs and acts centrally.6,7 Thus tolcapone may even reduce
               homocysteine levels within the brain and thus the associated neurotoxic effects of
                   homocysteine.58,59 Central COMT activation caused a
               sustained synthesis of homocysteine in astrocytes and transport of this amino acid
               to neurons. 
Positive_regulation (activation) of COMT in neurons associated with catechol-o-methyltransferase
4) Confidence 0.41 Published 2009 Journal Patient Prefer Adherence Section Body Doc Link PMC2778405 Disease Relevance 0 Pain Relevance 0.29
During the same time the probenecid-induced accumulation of HVA and DOPAC was reduced in the striatum in relation to probenecid-treated tolerant/dependent controls. 20 min after precipitation of withdrawal by naloxone, the striatal concentration of 3-methoxytyramine was decreased by about 40%, while the activity of the DA metabolizing enzymes, MAO and COMT, remained unchanged.
Neg (unchanged) Positive_regulation (unchanged) of COMT in striatum associated with narcan and withdrawal
5) Confidence 0.40 Published 1977 Journal Eur. J. Pharmacol. Section Abstract Doc Link 560969 Disease Relevance 0 Pain Relevance 0.66
Additional experiments demonstrated that blockade of these phagocyte-derived catecholamines (by pharmacological blockade of catecholamine generating enzymes or blockade of adrenoceptors) greatly attenuated lung inflammatory injury, while the opposite was the case when the catecholamine-inactivating enzymes catechol-O-methyltransferase (COMT) and monoamine oxidase (MAO) were inhibited [8].
Positive_regulation (inactivating) of COMT in phagocyte associated with catechol-o-methyltransferase, inflammation, catecholamine, injury and monoamine
6) Confidence 0.38 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2636885 Disease Relevance 0.69 Pain Relevance 0.85
Additional experiments demonstrated that blockade of these phagocyte-derived catecholamines (by pharmacological blockade of catecholamine generating enzymes or blockade of adrenoceptors) greatly attenuated lung inflammatory injury, while the opposite was the case when the catecholamine-inactivating enzymes catechol-O-methyltransferase (COMT) and monoamine oxidase (MAO) were inhibited [8].
Positive_regulation (inactivating) of catechol-O-methyltransferase in phagocyte associated with catechol-o-methyltransferase, inflammation, catecholamine, injury and monoamine
7) Confidence 0.38 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2636885 Disease Relevance 0.69 Pain Relevance 0.84
Another frequently studied gene is catechol-o-methyltransferase (COMT) that is related to the monoamine catabolism.
Positive_regulation (related) of catechol-o-methyltransferase associated with monoamine
8) Confidence 0.24 Published 2010 Journal Qual Life Res Section Body Doc Link PMC2977055 Disease Relevance 0.80 Pain Relevance 0.30
Additionally, chronic opiate administration has been shown to increase the levels of a number of G-proteins and phosphoproteins including the catecholamine synthesizing enzyme, tyrosine hydroxylase (TH).
Positive_regulation (increase) of catecholamine synthesizing enzyme associated with catecholamine and opiate
9) Confidence 0.03 Published 1995 Journal J. Comp. Neurol. Section Abstract Doc Link 8847409 Disease Relevance 0 Pain Relevance 1.15

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