INT287101

Context Info Confidence 0.04 First Reported 2009 Last Reported 2009 Negated 0 Speculated 0 Reported most in Abstract Documents 1 Total Number 1 Disease Relevance 0.58 Pain Relevance 0.24

mitochondrion (Mutyh) hydrolase activity, acting on glycosyl bonds (Mutyh) extracellular region (Bdnf) nucleus (Mutyh) cytoplasmic membrane-bounded vesicle (Bdnf)

Bdnf (Mus musculus) Mutyh (Mus musculus)

Pain Link Frequency Relevance Heat Lasting pain 2 99.96 Central nervous system 1 97.56 Neuropathic pain 4 65.20 spinal dorsal horn 5 53.20 Inflammation 11 46.72 qutenza 10 5.00 Pain 9 5.00 withdrawal 5 5.00 Dorsal horn 4 5.00 intrathecal 2 5.00

Disease Link Frequency Relevance Heat Nociception 13 100.00 Pain 11 99.96 Acquired Immune Deficiency Syndrome Or Hiv Infection 3 66.40 Neuropathic Pain 7 65.20 INFLAMMATION 12 46.72 Hypersensitivity 14 5.00 Targeted Disruption 6 5.00 Hyperalgesia 3 5.00 Ganglion Cysts 2 5.00 Nervous System Injury 2 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

In animal models of chronic pain, BDNF exerts its effects on nociceptive processing by binding to the full-length receptor tropomyosin-related kinase B (trkB.FL) and transducing intracellular signaling to produce nocifensive behaviors.

BDNF Binding (binding) of full-length receptor tropomyosin-related kinase B associated with nociception and lasting pain

1) Confidence 0.04 Published 2009 Journal Mol Pain Section Abstract Doc Link PMC2777863 Disease Relevance 0.58 Pain Relevance 0.24

General Comments

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