INT287104

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Context Info
Confidence 0.20
First Reported 2009
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 5
Disease Relevance 3.29
Pain Relevance 1.26

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Ntrk2) cytosol (Ntrk2) nucleus (T)
plasma membrane (Ntrk2) DNA binding (T) kinase activity (Ntrk2)
Anatomy Link Frequency
tail 2
Ntrk2 (Mus musculus)
T (Mus musculus)
Pain Link Frequency Relevance Heat
Lasting pain 10 86.96 High High
Central nervous system 5 84.60 Quite High
Neuropathic pain 20 82.80 Quite High
spinal dorsal horn 25 70.80 Quite High
Hyperalgesia 10 66.44 Quite High
medulla 5 65.12 Quite High
Inflammation 55 64.32 Quite High
Pain 45 53.12 Quite High
Root ganglion neuron 10 33.20 Quite Low
qutenza 50 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Nociception 65 88.56 High High
Pain 55 86.96 High High
Acquired Immune Deficiency Syndrome Or Hiv Infection 15 84.00 Quite High
Neuropathic Pain 35 82.80 Quite High
Hypersensitivity 70 79.64 Quite High
Nervous System Injury 10 77.72 Quite High
Targeted Disruption 30 74.80 Quite High
Disease 5 73.28 Quite High
Death 5 67.28 Quite High
Hyperalgesia 15 66.44 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Since trkB.T1 heterodimerization with trkB.FL inhibits trans-autophosphorylation of the trkB.FL kinase domain, studies support a model in which trkB.T1 functions to reduce BDNF signaling [17-22].
trkB Binding (heterodimerization) of T1
1) Confidence 0.20 Published 2009 Journal Mol Pain Section Body Doc Link PMC2777863 Disease Relevance 0.66 Pain Relevance 0.23
Since trkB.T1 heterodimerization with trkB.FL inhibits trans-autophosphorylation of the trkB.FL kinase domain, studies support a model in which trkB.T1 functions to reduce BDNF signaling [17-22].
trkB Binding (heterodimerization) of T1
2) Confidence 0.15 Published 2009 Journal Mol Pain Section Body Doc Link PMC2777863 Disease Relevance 0.66 Pain Relevance 0.24
Since trkB.T1 heterodimerization with trkB.FL inhibits trans-autophosphorylation of the trkB.FL kinase domain, studies support a model in which trkB.T1 functions to reduce BDNF signaling [17-22].
trkB Binding (heterodimerization) of T1
3) Confidence 0.15 Published 2009 Journal Mol Pain Section Body Doc Link PMC2777863 Disease Relevance 0.66 Pain Relevance 0.24
TrkB.T1 binds BDNF with high affinity; however the unique 11 amino acid intracellular cytoplasmic tail lacks the kinase domain of trkB.FL.
TrkB Binding (binds) of T1 in tail
4) Confidence 0.13 Published 2009 Journal Mol Pain Section Abstract Doc Link PMC2777863 Disease Relevance 0.65 Pain Relevance 0.28
TrkB.T1 binds BDNF with high affinity; however the unique 11 amino acid intracellular cytoplasmic tail lacks the kinase domain of trkB.FL.
TrkB Binding (binds) of T1 in tail
5) Confidence 0.13 Published 2009 Journal Mol Pain Section Abstract Doc Link PMC2777863 Disease Relevance 0.65 Pain Relevance 0.28

General Comments

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