INT287124

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Context Info
Confidence 0.38
First Reported 2009
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.22
Pain Relevance 0.29

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Comt) plasma membrane (Comt) cytoplasm (Comt)
Anatomy Link Frequency
brain 2
Comt (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Catechol-O-methyltransferase 58 100.00 Very High Very High Very High
Dopamine 19 90.24 High High
Bioavailability 6 5.00 Very Low Very Low Very Low
agonist 4 5.00 Very Low Very Low Very Low
dopamine receptor 1 5.00 Very Low Very Low Very Low
depression 1 5.00 Very Low Very Low Very Low
abdominal pain 1 5.00 Very Low Very Low Very Low
antidepressant 1 5.00 Very Low Very Low Very Low
headache 1 5.00 Very Low Very Low Very Low
Catecholamine 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Disease 44 78.00 Quite High
Cognitive Disorder 4 5.00 Very Low Very Low Very Low
Dyskinesias 4 5.00 Very Low Very Low Very Low
Increased Venous Pressure Under Development 4 5.00 Very Low Very Low Very Low
Diarrhoea 3 5.00 Very Low Very Low Very Low
Hepatotoxicity 2 5.00 Very Low Very Low Very Low
Stress 2 5.00 Very Low Very Low Very Low
Hypokinesia 1 5.00 Very Low Very Low Very Low
Tremor 1 5.00 Very Low Very Low Very Low
Abdominal Pain 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
A further development was the introduction of COMT inhibitors, which decrease
               peripheral LD degradation to 3-O-methyldopa (3-OMD) and thus further increase the
               delivery of LD to the brain.4,5 Two COMT-inhibitors, the only
               peripheral-acting entacapone (EN) and the additionally central-acting
                   tolcapone,6,7 are currently marketed as adjuncts
               to LD/DDI application. 
Negative_regulation (decrease) of Protein_catabolism (degradation) of COMT in brain associated with catechol-o-methyltransferase
1) Confidence 0.38 Published 2009 Journal Patient Prefer Adherence Section Body Doc Link PMC2778405 Disease Relevance 0.22 Pain Relevance 0.29

General Comments

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