INT287126

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Context Info
Confidence 0.37
First Reported 2009
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.78
Pain Relevance 0.25

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Comt) plasma membrane (Comt) cytoplasm (Comt)
Comt (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Catechol-O-methyltransferase 58 100.00 Very High Very High Very High
antidepressant 1 67.08 Quite High
agonist 4 66.28 Quite High
Dopamine 19 65.92 Quite High
headache 1 61.76 Quite High
abdominal pain 1 49.92 Quite Low
Bioavailability 6 5.00 Very Low Very Low Very Low
dopamine receptor 1 5.00 Very Low Very Low Very Low
depression 1 5.00 Very Low Very Low Very Low
Catecholamine 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Hepatotoxicity 2 99.64 Very High Very High Very High
Syndrome 1 92.88 High High
Malignant Neoplastic Disease 1 92.32 High High
Rhabdomyolysis 1 90.64 High High
Disease 44 88.68 High High
Diarrhoea 3 83.68 Quite High
Headache 1 61.76 Quite High
Dyskinesias 4 53.68 Quite High
Abdominal Pain 1 49.92 Quite Low
Cognitive Disorder 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
One assumes that patients with mutations in the
               UDP-glucuronosyltransferase 1A9 gene, which leads to defective glucuronidation
               activity, may be predisposed to COMT inhibitor-induced hepatotoxicity.90 Therefore tolcapone was
               temporarily withdrawn nearly all over the world. 
Negative_regulation (predisposed) of Negative_regulation (inhibitor) of COMT associated with catechol-o-methyltransferase and hepatotoxicity
1) Confidence 0.37 Published 2009 Journal Patient Prefer Adherence Section Body Doc Link PMC2778405 Disease Relevance 0.78 Pain Relevance 0.25

General Comments

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