INT287131

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Context Info
Confidence 0.03
First Reported 2009
Last Reported 2009
Negated 1
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.06
Pain Relevance 0.23

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (NT5E, Comt) cytoplasm (NT5E, Comt) mitochondrion (Comt)
small molecule metabolic process (NT5E) DNA metabolic process (NT5E)
NT5E (Homo sapiens)
Comt (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Catechol-O-methyltransferase 58 100.00 Very High Very High Very High
Dopamine 19 61.12 Quite High
dopamine receptor 1 25.04 Quite Low
Bioavailability 6 5.00 Very Low Very Low Very Low
agonist 4 5.00 Very Low Very Low Very Low
depression 1 5.00 Very Low Very Low Very Low
abdominal pain 1 5.00 Very Low Very Low Very Low
antidepressant 1 5.00 Very Low Very Low Very Low
headache 1 5.00 Very Low Very Low Very Low
Catecholamine 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Disease 44 60.96 Quite High
Drug Induced Neurotoxicity 1 20.72 Low Low
Cognitive Disorder 4 5.00 Very Low Very Low Very Low
Dyskinesias 4 5.00 Very Low Very Low Very Low
Increased Venous Pressure Under Development 4 5.00 Very Low Very Low Very Low
Diarrhoea 3 5.00 Very Low Very Low Very Low
Hepatotoxicity 2 5.00 Very Low Very Low Very Low
Stress 2 5.00 Very Low Very Low Very Low
Hypokinesia 1 5.00 Very Low Very Low Very Low
Tremor 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
There is also some circumstantial evidence from the FIRST-STEP and ELLDOPA study that
               COMT inhibition with EN also reduces the frequency of motor complications. 
Negative_regulation (reduces) of EN Neg (inhibition) Binding (inhibition) of COMT associated with catechol-o-methyltransferase
1) Confidence 0.03 Published 2009 Journal Patient Prefer Adherence Section Body Doc Link PMC2778405 Disease Relevance 0.06 Pain Relevance 0.23

General Comments

This test has worked.

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