INT287132

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Context Info
Confidence 0.03
First Reported 2009
Last Reported 2009
Negated 2
Speculated 0
Reported most in Body
Documents 1
Total Number 3
Disease Relevance 0.11
Pain Relevance 0.73

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (NT5E, Comt) cytoplasm (NT5E, Comt) mitochondrion (Comt)
small molecule metabolic process (NT5E) DNA metabolic process (NT5E)
NT5E (Homo sapiens)
Comt (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Catechol-O-methyltransferase 174 100.00 Very High Very High Very High
Dopamine 57 99.80 Very High Very High Very High
dopamine receptor 3 76.00 Quite High
Bioavailability 18 46.40 Quite Low
agonist 12 5.00 Very Low Very Low Very Low
depression 3 5.00 Very Low Very Low Very Low
abdominal pain 3 5.00 Very Low Very Low Very Low
antidepressant 3 5.00 Very Low Very Low Very Low
headache 3 5.00 Very Low Very Low Very Low
Catecholamine 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Disease 132 59.92 Quite High
Tremor 3 50.48 Quite High
Dyskinesias 12 43.28 Quite Low
Drug Induced Neurotoxicity 3 19.68 Low Low
Cognitive Disorder 12 5.00 Very Low Very Low Very Low
Increased Venous Pressure Under Development 12 5.00 Very Low Very Low Very Low
Diarrhoea 9 5.00 Very Low Very Low Very Low
Hepatotoxicity 6 5.00 Very Low Very Low Very Low
Stress 6 5.00 Very Low Very Low Very Low
Hypokinesia 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
There is also some circumstantial evidence from the FIRST-STEP and ELLDOPA study that
               COMT inhibition with EN also reduces the frequency of motor complications. 
EN Neg (inhibition) Binding (inhibition) of COMT associated with catechol-o-methyltransferase
1) Confidence 0.03 Published 2009 Journal Patient Prefer Adherence Section Body Doc Link PMC2778405 Disease Relevance 0.06 Pain Relevance 0.23
But COMT inhibition with
               EN increased the recovery rate of the salt [13C]-sodium-octanoate.25,29,30

The anti-acid scenario of COMT inhibition

EN Neg (inhibition) Binding (inhibition) of COMT associated with catechol-o-methyltransferase
2) Confidence 0.03 Published 2009 Journal Patient Prefer Adherence Section Body Doc Link PMC2778405 Disease Relevance 0 Pain Relevance 0.12
Additional COMT inhibition with LD/DDI application is also suspected of preventing
               motor complications since the rise and fall of LD and also accordingly of striatal
               dopamine are less intense during COMT inhibition, ie, with EN. 
EN Binding (intense) of COMT associated with catechol-o-methyltransferase and dopamine
3) Confidence 0.03 Published 2009 Journal Patient Prefer Adherence Section Body Doc Link PMC2778405 Disease Relevance 0.05 Pain Relevance 0.38

General Comments

This test has worked.

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