INT28714

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Context Info
Confidence 0.41
First Reported 1989
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 10
Total Number 10
Disease Relevance 6.90
Pain Relevance 1.60

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Csf3) extracellular region (Csf3) enzyme binding (Csf3)
Anatomy Link Frequency
granulocyte 3
stem cells 2
macrophages 1
forebrain 1
Csf3 (Mus musculus)
Pain Link Frequency Relevance Heat
Pain 10 100.00 Very High Very High Very High
Paracetamol 2 99.76 Very High Very High Very High
Inflammatory mediators 3 99.32 Very High Very High Very High
Spinal cord 14 98.64 Very High Very High Very High
Inflammatory response 17 96.80 Very High Very High Very High
Angina 1 93.28 High High
headache 4 86.16 High High
cytokine 11 84.28 Quite High
Sciatic nerve 15 82.32 Quite High
Inflammation 15 76.40 Quite High
Disease Link Frequency Relevance Heat
Neutropenia 11 100.00 Very High Very High Very High
Pain 8 100.00 Very High Very High Very High
Wound Healing 1 100.00 Very High Very High Very High
Infection 4 99.48 Very High Very High Very High
Pulmonary Alveolar Proteinosis 6 99.28 Very High Very High Very High
INFLAMMATION 36 99.12 Very High Very High Very High
Adhesions 3 98.92 Very High Very High Very High
Thrombocytopenia 3 98.44 Very High Very High Very High
Mouth Ulcer 1 97.96 Very High Very High Very High
Disease 25 97.24 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
 ;-promoter directed G-CSF overexpression in the forebrain leads to a strong elevation of G-CSF levels in the neonatal brain and spinal cord (P9; 28.00 ± 11.60 vs 0.24 ± 0.23 pg/mg tissue protein; p < 0.05) (Figure 3).
Negative_regulation (elevation) of G-CSF in forebrain associated with spinal cord
1) Confidence 0.41 Published 2010 Journal BMC Neurosci Section Body Doc Link PMC2844381 Disease Relevance 0.20 Pain Relevance 0.26
Mice genetically deficient in granulocyte macrophagecolony stimulating factor (GM-CSF) show an alveolar proteinosis.
Negative_regulation (deficient) of granulocyte macrophagecolony stimulating factor in granulocyte associated with pulmonary alveolar proteinosis
2) Confidence 0.39 Published 2003 Journal Rev Med Chir Soc Med Nat Iasi Section Abstract Doc Link 14756054 Disease Relevance 1.14 Pain Relevance 0.09
Additionally, we find that antagonism of miR-155 leads to down-regulation of G-CSF, a regulator of granulopoiesis, produced by activated macrophages during acute inflammatory responses.
Negative_regulation (regulation) of G-CSF in macrophages associated with inflammatory response
3) Confidence 0.36 Published 2009 Journal Nucleic Acids Research Section Body Doc Link PMC2761263 Disease Relevance 0.59 Pain Relevance 0.28
Granulocyte-colony stimulating factor (G-CSF), a hematopoietic growth factor, is widely used to accelerate recovery from neutropenia after severe chemotherapy, both decreasing the risk of infection and mobilizing peripheral blood stem cells.
Negative_regulation (decreasing) of Granulocyte-colony stimulating factor in stem cells associated with neutropenia and infection
4) Confidence 0.32 Published 2005 Journal Haematologica Section Abstract Doc Link 15753051 Disease Relevance 0.81 Pain Relevance 0.21
G-CSF was well tolerated, although mild bone pain occurred and was reduced with acetaminophen.
Negative_regulation (reduced) of G-CSF associated with pain and paracetamol
5) Confidence 0.32 Published 1989 Journal J. Clin. Oncol. Section Abstract Doc Link 2789274 Disease Relevance 0.52 Pain Relevance 0.20
Each donor received the G-CSF subcutaneously at a dose of 10 µg kg?
Negative_regulation (received) of G-CSF
6) Confidence 0.30 Published 2010 Journal Transfusion Medicine (Oxford, England) Section Body Doc Link PMC2871169 Disease Relevance 0.19 Pain Relevance 0
Because of the effectiveness of granulocyte colony-stimulating factor (G-CSF) in wound healing, it may also be useful for the treatment of oral ulcers (OU) and genital ulcers (GU) of BD.
Negative_regulation (effectiveness) of G-CSF in granulocyte associated with mouth ulcer, ulcers, wound healing and disease
7) Confidence 0.28 Published 2006 Journal J Eur Acad Dermatol Venereol Section Abstract Doc Link 16922940 Disease Relevance 0.83 Pain Relevance 0.09
Granulocyte-colony stimulating factor (G-CSF), a hematopoietic growth factor, is widely used to accelerate recovery from neutropenia after severe chemotherapy, both decreasing the risk of infection and mobilizing peripheral blood stem cells.
Negative_regulation (decreasing) of G-CSF in stem cells associated with neutropenia and infection
8) Confidence 0.28 Published 2005 Journal Haematologica Section Abstract Doc Link 15753051 Disease Relevance 0.81 Pain Relevance 0.21
The Egr-1 mice exhibited decreased levels of hepatic inflammatory mediators compared with WT controls with a decrease in hepatic mRNA levels of IL-6 by 42%, granulocyte colony-stimulating factor by 39%, and intracellular adhesion molecule 1 by 43%.
Negative_regulation (decrease) of granulocyte colony-stimulating factor in granulocyte associated with inflammatory mediators and adhesions
9) Confidence 0.26 Published 2007 Journal Shock Section Abstract Doc Link 17224790 Disease Relevance 1.25 Pain Relevance 0.26
Nonetheless, the published data support that growth factors' use is safe [39–41], suggesting that their routine use probably rests on economic factors, which is the balance between G-SCF treatment cost and potential G-CSF related decline in hospitalization days.
Negative_regulation (decline) of G-CSF
10) Confidence 0.22 Published 2010 Journal Journal of Oncology Section Body Doc Link PMC2902223 Disease Relevance 0.54 Pain Relevance 0

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