INT28715

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Context Info
Confidence 0.43
First Reported 1987
Last Reported 2005
Negated 0
Speculated 0
Reported most in Abstract
Documents 7
Total Number 7
Disease Relevance 0.97
Pain Relevance 3.06

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Crh) extracellular region (Crh) response to stress (Crh)
cytoplasm (Crh)
Anatomy Link Frequency
hippocampus 4
plasma 2
Crh (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Enkephalin 14 99.70 Very High Very High Very High
Locus ceruleus 10 99.68 Very High Very High Very High
narcan 3 99.40 Very High Very High Very High
Hippocampus 12 97.72 Very High Very High Very High
amygdala 19 97.08 Very High Very High Very High
dexamethasone 2 94.44 High High
opioid receptor 1 90.00 High High
Opioid 5 88.80 High High
palliative 2 83.96 Quite High
medulla 3 80.72 Quite High
Disease Link Frequency Relevance Heat
Stress 8 100.00 Very High Very High Very High
Disease 4 93.56 High High
Syndrome 2 85.24 High High
Pituitary Cancer 1 80.08 Quite High
Anxiety Disorder 8 45.92 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Previously, we demonstrated that transection of the fimbria/fornix blocked the excitatory effect of corticotropin-releasing hormone (CRH) on startle (CRH-enhanced startle), suggesting that the hippocampus and its efferent target areas that communicate via the fimbria may be critically involved in CRH-enhanced startle.
Negative_regulation (blocked) of Regulation (effect) of CRH in hippocampus associated with hippocampus
1) Confidence 0.43 Published 1997 Journal J. Neurosci. Section Abstract Doc Link 9236251 Disease Relevance 0 Pain Relevance 0.32
Previously, we demonstrated that transection of the fimbria/fornix blocked the excitatory effect of corticotropin-releasing hormone (CRH) on startle (CRH-enhanced startle), suggesting that the hippocampus and its efferent target areas that communicate via the fimbria may be critically involved in CRH-enhanced startle.
Negative_regulation (blocked) of Regulation (effect) of corticotropin-releasing hormone in hippocampus associated with hippocampus
2) Confidence 0.43 Published 1997 Journal J. Neurosci. Section Abstract Doc Link 9236251 Disease Relevance 0 Pain Relevance 0.29
Naloxone pretreatment (5 mg/kg, i.v.) restored ACTH and pPVN CRH mRNA responses after IL-1beta in pregnant rats but reduced the CRH mRNA response in virgins without affecting ACTH.
Negative_regulation (restored) of Regulation (responses) of CRH mRNA associated with narcan
3) Confidence 0.39 Published 2005 Journal J. Neurosci. Section Abstract Doc Link 15917452 Disease Relevance 0 Pain Relevance 0.51
Light-level densitometry revealed robust decreases in CRF immunoreactivity in the LC and mPB on the side ipsilateral to the lesion but little or no change in ENK immunoreactivity, confirming previous studies of the mPB.
Negative_regulation (decreases) of Regulation (immunoreactivity) of CRF associated with locus ceruleus and enkephalin
4) Confidence 0.36 Published 2003 Journal J. Comp. Neurol. Section Abstract Doc Link 14566941 Disease Relevance 0 Pain Relevance 1.55
During ketoconazole, cortisol was lowered to normal levels and its response to oCRH was impaired.
Negative_regulation (impaired) of Regulation (response) of oCRH
5) Confidence 0.19 Published 1987 Journal Horm. Metab. Res. Suppl. Section Abstract Doc Link 2832292 Disease Relevance 0.33 Pain Relevance 0.08
Glucocorticoid inhibition of stress-induced changes in hypothalamic corticotrophin-releasing factor messenger RNA and proenkephalin A messenger RNA.
Negative_regulation (inhibition) of Regulation (changes) of corticotrophin-releasing factor associated with stress and enkephalin
6) Confidence 0.15 Published 1989 Journal Neuropeptides Section Title Doc Link 2789345 Disease Relevance 0.42 Pain Relevance 0.25
After ketoconazole treatment, both plasma cortisol and aldosterone were lowered and their response to oCRH was impaired.
Negative_regulation (impaired) of Regulation (response) of oCRH in plasma
7) Confidence 0.00 Published 1987 Journal Clin. Endocrinol. (Oxf) Section Abstract Doc Link 2830063 Disease Relevance 0.22 Pain Relevance 0.06

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