INT28717

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Context Info
Confidence 0.29
First Reported 1989
Last Reported 2010
Negated 1
Speculated 1
Reported most in Abstract
Documents 2
Total Number 3
Disease Relevance 1.40
Pain Relevance 0.24

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (CRH) extracellular space (CRH) extracellular region (CRH)
response to stress (CRH)
Anatomy Link Frequency
PVN 3
neurons 1
CRH (Homo sapiens)
Pain Link Frequency Relevance Heat
dexamethasone 6 100.00 Very High Very High Very High
opiate 2 59.84 Quite High
depression 6 29.48 Quite Low
Enkephalin 2 25.00 Low Low
Inflammation 9 5.00 Very Low Very Low Very Low
corticosteroid 3 5.00 Very Low Very Low Very Low
cytokine 2 5.00 Very Low Very Low Very Low
alcohol 1 5.00 Very Low Very Low Very Low
Autonomic response 1 5.00 Very Low Very Low Very Low
headache 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Stress 108 100.00 Very High Very High Very High
Schizophrenia 166 99.90 Very High Very High Very High
Psychosis 34 65.28 Quite High
Suicidal Behaviour 9 49.16 Quite Low
Depression 10 29.48 Quite Low
Injury 12 5.00 Very Low Very Low Very Low
INFLAMMATION 9 5.00 Very Low Very Low Very Low
Disease 9 5.00 Very Low Very Low Very Low
Birth Weight 4 5.00 Very Low Very Low Very Low
Anxiety Disorder 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We have examined the effects of localised administration of the synthetic glucocorticoid dexamethasone on basal and stress-induced levels of mRNA for both corticotrophin-releasing factor (CRF) and proenkephalin A, in parvocellular neurons of the paraventricular nucleus (PVN).
Spec (examined) Regulation (effects) of in neurons Spec (examined) Positive_regulation (stress-induced) of CRF in PVN associated with stress and dexamethasone
1) Confidence 0.29 Published 1989 Journal Neuropeptides Section Abstract Doc Link 2789345 Disease Relevance 0.38 Pain Relevance 0.09
Unilateral implants of cholesterol directly over the PVN had no effect on either basal or stress-induced increase of CRF and proenkephalin A message.
Neg (no) Regulation (effect) of Positive_regulation (increase) of CRF in PVN associated with stress
2) Confidence 0.29 Published 1989 Journal Neuropeptides Section Abstract Doc Link 2789345 Disease Relevance 0.41 Pain Relevance 0.15
Four of these found basal CRH to be similar in schizophrenia and controls, and in only one of these studies (Banki et al. 1987) was there any evidence for increased basal CRH in schizophrenia.
Regulation (controls) of Positive_regulation (increased) of CRH associated with schizophrenia
3) Confidence 0.17 Published 2010 Journal Journal of Psychopharmacology (Oxford, England) Section Body Doc Link PMC2951595 Disease Relevance 0.61 Pain Relevance 0

General Comments

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