INT2872

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Context Info
Confidence 0.67
First Reported 1977
Last Reported 2009
Negated 1
Speculated 2
Reported most in Abstract
Documents 10
Total Number 13
Disease Relevance 3.26
Pain Relevance 7.47

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Maoa) oxidoreductase activity (Maoa)
Anatomy Link Frequency
phagocyte 2
striatum 1
veins 1
preoptic area 1
Maoa (Rattus norvegicus)
Pain Link Frequency Relevance Heat
monoamine 20 100.00 Very High Very High Very High
agonist 15 100.00 Very High Very High Very High
Catechol-O-methyltransferase 10 100.00 Very High Very High Very High
Clonidine 1 100.00 Very High Very High Very High
Catecholamine 95 99.98 Very High Very High Very High
narcan 11 99.84 Very High Very High Very High
Dopamine 27 99.76 Very High Very High Very High
dexamethasone 8 99.70 Very High Very High Very High
Serotonin 9 99.22 Very High Very High Very High
fluoxetine 7 99.10 Very High Very High Very High
Disease Link Frequency Relevance Heat
Injury 20 98.86 Very High Very High Very High
INFLAMMATION 78 98.72 Very High Very High Very High
Urological Neuroanatomy 9 97.16 Very High Very High Very High
Aids-related Complex 2 96.92 Very High Very High Very High
Depression 2 94.48 High High
Fibromyalgia 1 93.60 High High
Conversion Disorder 1 93.12 High High
Syndrome 1 89.84 High High
Headache 3 75.00 Quite High
Anxiety Disorder 3 75.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
MAO activity increased in all the areas studied, but more appreciable change was observed in medial preoptic area (mPOA), the ME-ARC region, and the cortex.
Positive_regulation (increased) of MAO in preoptic area associated with aids-related complex and urological neuroanatomy
1) Confidence 0.67 Published 1998 Journal Brain Res. Bull. Section Abstract Doc Link 9766393 Disease Relevance 0.29 Pain Relevance 0.86
Colchicine administration caused an increase of TH-like immunoreactivity and MAO activity.
Spec (like) Positive_regulation (increase) of MAO
2) Confidence 0.62 Published 1991 Journal Cell. Mol. Biol. Section Abstract Doc Link 1682049 Disease Relevance 0 Pain Relevance 0.21
Exploration of the peripheral neuromuscular junctions (in the iris by pupillometry, and in veins by computerized venotest) indicates an increased monoamine receptor sensitivity. 5-HT vein sensitivity is particularly impressive (up to 1,000 times).
Positive_regulation (increased) of monoamine receptor in veins associated with monoamine
3) Confidence 0.54 Published 1978 Journal Res Clin Stud Headache Section Abstract Doc Link 725253 Disease Relevance 0.68 Pain Relevance 0.49
The selective serotonin (5-HT) uptake blockers chlorimipramine and fluoxetine as well as the selective monoamine oxidase (MAO) inhibitors clorgyline and deprenyl induced, after prenatal exposure, a down-regulation of 3H-IMI binding sites at postnatal day 25.
Positive_regulation (induced) of MAO associated with serotonin, monoamine and fluoxetine
4) Confidence 0.49 Published 1990 Journal Life Sci. Section Abstract Doc Link 2161976 Disease Relevance 0 Pain Relevance 0.48
Pretreatment with alpha-methyl-tyrosine to block dopamine synthesis antagonized the persistent depletion of dopamine by amphetamine, but pretreatment with an inhibitor of monoamine oxidase to increase that dopamine concentration had no effect.
Positive_regulation (increase) of monoamine oxidase associated with dopamine and monoamine
5) Confidence 0.47 Published 1982 Journal Neuropharmacology Section Abstract Doc Link 7110533 Disease Relevance 0 Pain Relevance 0.76
Reductions of SAP and intentions with concomitant reductions of crossings (nonspecific antiambivalent effects) were established for the alpha 2-adrenoceptor agonist clonidine and the MAO inhibitor clorgyline.
Positive_regulation (established) of MAO associated with agonist and clonidine
6) Confidence 0.36 Published 1995 Journal Psychopharmacology (Berl.) Section Abstract Doc Link 8539344 Disease Relevance 0.07 Pain Relevance 0.35
Additional experiments demonstrated that blockade of these phagocyte-derived catecholamines (by pharmacological blockade of catecholamine generating enzymes or blockade of adrenoceptors) greatly attenuated lung inflammatory injury, while the opposite was the case when the catecholamine-inactivating enzymes catechol-O-methyltransferase (COMT) and monoamine oxidase (MAO) were inhibited [8].
Positive_regulation (inactivating) of MAO in phagocyte associated with catechol-o-methyltransferase, inflammation, catecholamine, injury and monoamine
7) Confidence 0.34 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2636885 Disease Relevance 0.71 Pain Relevance 0.86
Additional experiments demonstrated that blockade of these phagocyte-derived catecholamines (by pharmacological blockade of catecholamine generating enzymes or blockade of adrenoceptors) greatly attenuated lung inflammatory injury, while the opposite was the case when the catecholamine-inactivating enzymes catechol-O-methyltransferase (COMT) and monoamine oxidase (MAO) were inhibited [8].
Positive_regulation (inactivating) of monoamine oxidase in phagocyte associated with catechol-o-methyltransferase, inflammation, catecholamine, injury and monoamine
8) Confidence 0.34 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2636885 Disease Relevance 0.70 Pain Relevance 0.85
Serotonin (5-HT) activity was assessed from the accumulation observed after the administration of the monoamine oxidase inhibitor pargyline.
Positive_regulation (accumulation) of monoamine oxidase associated with serotonin and monoamine
9) Confidence 0.33 Published 1986 Journal Endocrinology Section Abstract Doc Link 3948769 Disease Relevance 0 Pain Relevance 0.39
Cisplatin significantly decreased monoamine oxidase activity but increased tryptophan hydroxylase (TPH) activity and TPH(1) mRNA expression in ileal tissue.
Positive_regulation (increased) of monoamine oxidase associated with monoamine
10) Confidence 0.32 Published 2008 Journal Eur. J. Pharmacol. Section Abstract Doc Link 18534574 Disease Relevance 0.40 Pain Relevance 0.60
Meloxicam and dexamethasone significantly restored the decreased monoamine oxidase activity and inhibited the cisplatin-induced increase in tryptophan hydroxylase activity toward the control levels.
Positive_regulation (restored) of monoamine oxidase associated with dexamethasone and monoamine
11) Confidence 0.32 Published 2008 Journal Eur. J. Pharmacol. Section Abstract Doc Link 18534574 Disease Relevance 0.40 Pain Relevance 0.64
During the same time the probenecid-induced accumulation of HVA and DOPAC was reduced in the striatum in relation to probenecid-treated tolerant/dependent controls. 20 min after precipitation of withdrawal by naloxone, the striatal concentration of 3-methoxytyramine was decreased by about 40%, while the activity of the DA metabolizing enzymes, MAO and COMT, remained unchanged.
Neg (unchanged) Positive_regulation (unchanged) of MAO in striatum associated with narcan and withdrawal
12) Confidence 0.20 Published 1977 Journal Eur. J. Pharmacol. Section Abstract Doc Link 560969 Disease Relevance 0 Pain Relevance 0.66
Although these data should be interpreted cautiously due to the small sample size, these results implicate TPH1 and SLC6A4 in general response, and HTR2A, TPH2, and MAOA in the specificity of response to fluoxetine.
Spec (implicate) Positive_regulation (implicate) of MAOA associated with fluoxetine
13) Confidence 0.06 Published 2004 Journal Mol. Psychiatry Section Abstract Doc Link 15052272 Disease Relevance 0 Pain Relevance 0.31

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