INT287205

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.45
First Reported 2009
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 5
Total Number 7
Disease Relevance 3.56
Pain Relevance 0.22

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Golgi apparatus (Htt) endoplasmic reticulum (Htt) mitochondrion organization (Htt)
embryo development (Htt) protein complex (Htt) cytoplasm (Htt)
Anatomy Link Frequency
HeLa 1
brains 1
adipocyte 1
Htt (Mus musculus)
Pain Link Frequency Relevance Heat
Pyramidal cell 8 95.60 Very High Very High Very High
Hippocampus 8 91.20 High High
gABA 3 69.40 Quite High
Central nervous system 10 61.72 Quite High
Glutamate 24 48.96 Quite Low
Endocannabinoid 1 46.96 Quite Low
Action potential 3 39.16 Quite Low
cerebral cortex 17 32.44 Quite Low
corticosteroid 2 24.48 Low Low
hyperexcitability 1 12.72 Low Low
Disease Link Frequency Relevance Heat
Disease 391 100.00 Very High Very High Very High
Targeted Disruption 168 100.00 Very High Very High Very High
Obesity 12 98.22 Very High Very High Very High
Weight Loss 30 96.68 Very High Very High Very High
Frailty 30 94.16 High High
Death 37 91.76 High High
Congenital Anomalies 10 74.88 Quite High
Lifespan 14 70.16 Quite High
Body Weight 9 66.08 Quite High
Neurodegenerative Disease 18 55.72 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Additional factors that might influence the propensity to form inclusions in a particular cell type could include expression level of the R6/2 transcript or Hdh gene, Htt proteolysis and protein folding and clearance networks.
Regulation (level) of Hdh
1) Confidence 0.45 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2778556 Disease Relevance 0.82 Pain Relevance 0.06
Adipose tissue-derived hormones that regulate food intake and glucose metabolism have been shown to be dysregulated in the R6/2 [50], [59] and HdhQ140 knock-in HD models [59], suggesting an intrinsic adipocyte dysfunction that may contribute to weight loss.
Regulation (dysregulated) of HD in adipocyte associated with targeted disruption, weight loss, obesity and disease
2) Confidence 0.39 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2778556 Disease Relevance 1.04 Pain Relevance 0
Furthermore, we titrated the amount of mutant Htt necessary for the interaction with Ku70 by using stable T-Rex┬ľHeLa cells in which expression levels of mutant Htt can be controlled by the concentration of tetracyclin in the culture medium.
Regulation (controlled) of mutant Htt in HeLa
3) Confidence 0.36 Published 2010 Journal The Journal of Cell Biology Section Body Doc Link PMC2867301 Disease Relevance 0 Pain Relevance 0
Expression levels of mutant and wild-type Htt-EGFP can be controlled via the tetracyclin concentration (Fig. 3 D).
Regulation (controlled) of wild-type Htt-EGFP
4) Confidence 0.36 Published 2010 Journal The Journal of Cell Biology Section Body Doc Link PMC2867301 Disease Relevance 0.07 Pain Relevance 0
In order to investigate the effect of rilmenidine treatment on levels of mutant huntingtin in the brains of transgenic, mice we measured the levels of the soluble htt-exon1 fragment using quantitative western blotting methods.
Spec (investigate) Regulation (effect) of mutant huntingtin in brains associated with targeted disruption
5) Confidence 0.27 Published 2010 Journal Human Molecular Genetics Section Body Doc Link PMC2865373 Disease Relevance 1.07 Pain Relevance 0
Immunohistochemistry was performed on coronal sections from rilmenidine-treated and control HD mice.
Regulation (control) of HD associated with disease
6) Confidence 0.20 Published 2010 Journal Human Molecular Genetics Section Body Doc Link PMC2865373 Disease Relevance 0.50 Pain Relevance 0.05
In R6/2 and YAC128 HD mice, alterations in glutamatergic function along the corticostriatal pathway change dynamically in a biphasic manner (Table 1).
Regulation (change) of HD
7) Confidence 0.17 Published 2010 Journal ASN NEURO Section Body Doc Link PMC2850512 Disease Relevance 0.06 Pain Relevance 0.12

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox