INT287206

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Context Info
Confidence 0.50
First Reported 2009
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 6
Total Number 7
Disease Relevance 3.27
Pain Relevance 0.57

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Golgi apparatus (Htt) endoplasmic reticulum (Htt) mitochondrion organization (Htt)
embryo development (Htt) protein complex (Htt) cytoplasm (Htt)
Anatomy Link Frequency
HeLa 2
brain 2
striatum 2
Htt (Mus musculus)
Pain Link Frequency Relevance Heat
medulla 14 95.76 Very High Very High Very High
Hippocampus 6 94.84 High High
cerebral cortex 14 94.32 High High
Clonidine 7 83.92 Quite High
Antinociceptive 1 82.68 Quite High
antinociception 1 76.64 Quite High
Central nervous system 13 62.16 Quite High
Neurotransmitter 5 5.00 Very Low Very Low Very Low
imagery 5 5.00 Very Low Very Low Very Low
Pain 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Disease 463 100.00 Very High Very High Very High
Targeted Disruption 167 100.00 Very High Very High Very High
Frailty 40 100.00 Very High Very High Very High
Weight Loss 31 95.28 Very High Very High Very High
Muscular Atrophy 9 94.00 High High
Tremor 11 84.32 Quite High
Weight Gain 3 82.88 Quite High
Death 26 81.52 Quite High
Sleep Disorders 3 81.36 Quite High
Heart Rate Under Development 1 79.48 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Furthermore, we titrated the amount of mutant Htt necessary for the interaction with Ku70 by using stable T-Rex┬ľHeLa cells in which expression levels of mutant Htt can be controlled by the concentration of tetracyclin in the culture medium.
Regulation (controlled) of Gene_expression (expression) of mutant Htt in HeLa
1) Confidence 0.50 Published 2010 Journal The Journal of Cell Biology Section Body Doc Link PMC2867301 Disease Relevance 0 Pain Relevance 0
Expression levels of mutant and wild-type Htt-EGFP can be controlled via the tetracyclin concentration (Fig. 3 D).
Regulation (controlled) of Gene_expression (Expression) of wild-type Htt-EGFP
2) Confidence 0.50 Published 2010 Journal The Journal of Cell Biology Section Body Doc Link PMC2867301 Disease Relevance 0.07 Pain Relevance 0
Additional factors that might influence the propensity to form inclusions in a particular cell type could include expression level of the R6/2 transcript or Hdh gene, Htt proteolysis and protein folding and clearance networks.
Regulation (level) of Gene_expression (expression) of Hdh
3) Confidence 0.45 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2778556 Disease Relevance 0.82 Pain Relevance 0.06
Therefore, we have demonstrated that the peripheral pathology documented in the R6/2 mice is not the result of the aberrant expression of a small N-terminal fragment of mutant Htt as it is also present in a genetically precise HD mouse model in which an expanded CAG repeat has been inserted into the mouse Hdh gene.
Neg (not) Regulation (result) of Gene_expression (expression) of Htt associated with disease
4) Confidence 0.45 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2778556 Disease Relevance 0.53 Pain Relevance 0
We are interested in understanding the factors that contribute to the tissue specificity of HD CAG somatic expansion, particularly, why the repeat is so unstable in the striatum.
Regulation (contribute) of Gene_expression (expansion) of HD in striatum associated with disease
5) Confidence 0.39 Published 2010 Journal BMC Syst Biol Section Body Doc Link PMC2856555 Disease Relevance 0.17 Pain Relevance 0
Shrinkage/atrophy of organs in the HdhQ150 knock-in mouse model
Regulation (atrophy) of Gene_expression (knock) of HdhQ150 associated with targeted disruption and frailty
6) Confidence 0.39 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2778556 Disease Relevance 0.90 Pain Relevance 0
To examine the effect of rilmenidine in vivo, we used the N171-82Q mice, which express the first 171 amino acids of mutant huntingtin under the control of the mouse prion promoter, which restricts expression of the protein mainly to the brain (26).
Regulation (under) of Gene_expression (express) of mutant huntingtin in brain
7) Confidence 0.12 Published 2010 Journal Human Molecular Genetics Section Body Doc Link PMC2865373 Disease Relevance 0.77 Pain Relevance 0.50

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