INT287207

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Context Info
Confidence 0.45
First Reported 2009
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 1.73
Pain Relevance 0.35

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Golgi apparatus (Htt) endoplasmic reticulum (Htt) mitochondrion organization (Htt)
embryo development (Htt) protein complex (Htt) cytoplasm (Htt)
Anatomy Link Frequency
neuronal 2
Htt (Mus musculus)
Pain Link Frequency Relevance Heat
Glutamate 24 93.20 High High
Central nervous system 8 61.72 Quite High
cerebral cortex 3 59.64 Quite High
Neurotransmitter 2 50.56 Quite High
nMDA receptor 12 5.00 Very Low Very Low Very Low
medulla 8 5.00 Very Low Very Low Very Low
Pyramidal cell 8 5.00 Very Low Very Low Very Low
gABA 3 5.00 Very Low Very Low Very Low
Action potential 3 5.00 Very Low Very Low Very Low
corticosteroid 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Frailty 26 95.92 Very High Very High Very High
Weight Loss 22 88.96 High High
Disease 191 87.68 High High
Neurodegenerative Disease 6 55.72 Quite High
Neuropathic Pain 4 53.00 Quite High
Targeted Disruption 64 50.00 Quite Low
Muscle Disease 8 47.44 Quite Low
Muscular Atrophy 6 18.48 Low Low
Body Weight Changes 2 10.00 Low Low
Obesity 12 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Additional factors that might influence the propensity to form inclusions in a particular cell type could include expression level of the R6/2 transcript or Hdh gene, Htt proteolysis and protein folding and clearance networks.
Regulation (level) of Protein_catabolism (proteolysis) of Hdh
1) Confidence 0.45 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2778556 Disease Relevance 0.82 Pain Relevance 0.06
Additional factors that might influence the propensity to form inclusions in a particular cell type could include expression level of the R6/2 transcript or Hdh gene, Htt proteolysis and protein folding and clearance networks.
Regulation (level) of Protein_catabolism (proteolysis) of Htt
2) Confidence 0.45 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2778556 Disease Relevance 0.82 Pain Relevance 0.06
How do the electrophysiological findings reviewed here contribute to our understanding of neuronal dysfunction and degeneration in HD?
Regulation (contribute) of Protein_catabolism (degeneration) of HD in neuronal
3) Confidence 0.17 Published 2010 Journal ASN NEURO Section Body Doc Link PMC2850512 Disease Relevance 0.09 Pain Relevance 0.22

General Comments

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