INT287241

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Context Info
Confidence 0.43
First Reported 2006
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 10
Total Number 10
Disease Relevance 2.68
Pain Relevance 1.38

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

anatomical structure formation involved in morphogenesis (BMP7) extracellular space (BMP7) growth (BMP7)
extracellular region (BMP7)
Anatomy Link Frequency
knees 1
microglial cells 1
BMP7 (Homo sapiens)
Pain Link Frequency Relevance Heat
Osteoarthritis 113 98.16 Very High Very High Very High
chemokine 12 96.72 Very High Very High Very High
cytokine 73 96.12 Very High Very High Very High
imagery 82 93.90 High High
Arthritis 15 92.92 High High
Inflammation 35 91.80 High High
metalloproteinase 37 77.44 Quite High
rheumatoid arthritis 2 75.16 Quite High
ischemia 10 74.84 Quite High
glial activation 1 54.04 Quite High
Disease Link Frequency Relevance Heat
Intervertebral Disk Degeneration 204 99.28 Very High Very High Very High
Osteoarthritis 61 98.16 Very High Very High Very High
Disease 43 95.04 Very High Very High Very High
Frailty 88 94.32 High High
Arthritis 19 92.92 High High
INFLAMMATION 35 91.80 High High
Middle Cerebral Artery Infarction 49 87.48 High High
Cytomegalovirus Infection 12 82.80 Quite High
Apoptosis 56 81.28 Quite High
Rheumatoid Arthritis 3 75.32 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In addition, the in vivo injection of AdLMP-1 resulted in a significant elevation of mRNA levels of LMP-1, BMP-2, and BMP-7.
Positive_regulation (elevation) of BMP-7
1) Confidence 0.43 Published 2006 Journal J Orthop Sci Section Body Doc Link PMC2778630 Disease Relevance 0.07 Pain Relevance 0.03
Yoon et al. reported that overexpression of LIM mineralization protein 1 (LMP-1),72 an intercellular protein, using an adenoviral vector (AdLMP-1) in rat IVD cells resulted in an increase of BMP-2 and BMP-7 gene expression and PG synthesis.73 BMP-2 and BMP-7 protein levels increased by two- to threefold.
Positive_regulation (increase) of BMP-7
2) Confidence 0.43 Published 2006 Journal J Orthop Sci Section Body Doc Link PMC2778630 Disease Relevance 0.08 Pain Relevance 0.04
The mRNA levels of BMP-2 and BMP-7 were also upregulated.
Positive_regulation (upregulated) of BMP-7
3) Confidence 0.43 Published 2006 Journal J Orthop Sci Section Body Doc Link PMC2778630 Disease Relevance 0.08 Pain Relevance 0.03
Yoon et al. reported that overexpression of LIM mineralization protein 1 (LMP-1),72 an intercellular protein, using an adenoviral vector (AdLMP-1) in rat IVD cells resulted in an increase of BMP-2 and BMP-7 gene expression and PG synthesis.73 BMP-2 and BMP-7 protein levels increased by two- to threefold.
Positive_regulation (increased) of BMP-7
4) Confidence 0.43 Published 2006 Journal J Orthop Sci Section Body Doc Link PMC2778630 Disease Relevance 0.08 Pain Relevance 0.04
BMP-7 was provided in a single dose 6-mL vial containing a sterile, lyophilized cake of BMP-7.
Positive_regulation (provided) of BMP-7
5) Confidence 0.41 Published 2010 Journal BMC Musculoskelet Disord Section Body Doc Link PMC2958989 Disease Relevance 0 Pain Relevance 0
Six weeks after the OP-1 injection, a restoration of disc height and MRI changes were observed and sustained for the entire experimental period, up to 24 weeks (Fig. 2).62 In another degeneration model using C-ABC, 4 weeks following the injection of C-ABC, OP-1 (100¼g/disc) injection restored the disc height up to 12 weeks after the OP-1 injection.63 These data suggest that OP-1 may be utilized in patients with disc degeneration who had received chemonucleolysis in the past that resulted in some loss of disc height.


Positive_regulation (utilized) of OP-1 associated with intervertebral disk degeneration and imagery
6) Confidence 0.40 Published 2006 Journal J Orthop Sci Section Body Doc Link PMC2778630 Disease Relevance 0.33 Pain Relevance 0.13
This is supported by the data of Honsawek et al., who described increased BMP-7 levels in knees of patients with progressive OA [19] The circumstance that in our trial only patients with circumscribed cartilage lesions were included (and patients with advanced OA were excluded) may make clear why synovial concentrations were mainly found below the detection level and, therefore, did not correlate with the clinical score.
Positive_regulation (increased) of BMP-7 in knees associated with osteoarthritis
7) Confidence 0.39 Published 2010 Journal BMC Musculoskelet Disord Section Body Doc Link PMC2920860 Disease Relevance 0.66 Pain Relevance 0.23
It is interesting to note that several neurotrophic factors such as GDNF, BDNF, BMP-7, CNTF and VEGF were upregulated in the transplanted HMO6 human microglial cells as compared to HMO6 cells in culture.
Positive_regulation (upregulated) of BMP-7 in microglial cells
8) Confidence 0.32 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2909196 Disease Relevance 0.37 Pain Relevance 0.37
Yoon et al. reported that overexpression of LIM mineralization protein 1 (LMP-1),72 an intercellular protein, using an adenoviral vector (AdLMP-1) in rat IVD cells resulted in an increase of BMP-2 and BMP-7 gene expression and PG synthesis.73 BMP-2 and BMP-7 protein levels increased by two- to threefold.
Positive_regulation (increase) of BMP-7
9) Confidence 0.19 Published 2006 Journal J Orthop Sci Section Body Doc Link PMC2778630 Disease Relevance 0.08 Pain Relevance 0.04
BMP-7, also termed osteogenic protein-1, has been studied extensively in vitro as well as in animal models, and results suggest that BMP-7 may be a candidate as a disease-modifying OA drug and also for posttraumatic arthritis.
Positive_regulation (termed) of osteogenic protein-1 associated with disease, osteoarthritis and arthritis
10) Confidence 0.09 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2911903 Disease Relevance 0.93 Pain Relevance 0.47

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